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For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Thromboxane synthase encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cytochrome P450 5A1; cytochrome P450, family 5, subfamily A, polypeptide 1; FLJ52771; Hydroperoxy icosatetraenoate dehydratase; platelet, cytochrome P450, subfamily V; ThromboxA ane synthase 1; thromboxane A synthase 1 (platelet); Thromboxane-A synthase; TXA synthase; TXS
Gene Aliases: BDPLT14; CYP5; CYP5A1; GHOSAL; TBXAS1; THAS; TS; TXAS; TXS
UniProt ID: (Human) E7EMU9, (Rat) P49430
Entrez Gene ID: (Human) 6916, (Rat) 24886
Molecular Function:
isomerase
metabolite interconversion enzyme
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