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Immunogen sequence: EFAAKHAKD SRFKAIEKMK DREALFNEFV AAARKKEKED SKTRGEKIKS DFFELLSNHH LDSQSRWSKV KDKVESDPRY KAVDSSSMRE DLFKQYIEKI AKNLDSEKEK ELERQARIEA SLREREREVQ KARSEQTKEI DREREQHKRE EAIQNFKALL SDMVRSSDVS WSDTRRTLRK DHRWESGSLL EREEKEKLFN EHIEALTKKK REHFRQLLDE TSAITLTSTW KEVKKIIKED PRCIKFSSSD RKKQREFEEY IRDKYITAKA DFRTLLKETK FITYRSKKLI QESDQHLKDV EKILQNDKRY LVLDCVPEER RKLIVAYVDD LDRRGPPPPP TASEPTRRST K (749-1098 aa encoded by BC111727)
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: co-activator of 150 kDa; coactivator of 150 kD; FBP 28; Formin-binding protein 28; MGC133200; p144; TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD; TATA box-binding protein-associated factor 2S; Transcription elongation regulator 1; transcription elongation regulator 1 (CA150); Transcription factor CA150; transcription factor CA150b
Gene Aliases: 2410022J09Rik; 2900090C16Rik; AI428505; CA150; CA150b; FBP23; FBP28; p144; TAF2S; TCERG1; Urn1
UniProt ID: (Human) O14776, (Mouse) Q8CGF7
Entrez Gene ID: (Human) 10915, (Rat) 307474, (Mouse) 56070
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