Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
TCF7L1/TCF7L2 Monoclonal Antibody (2B2D12), CoraLite® Plus 488
Application
FIGURE: 1 / 1
TCF7L1/TCF7L2 Antibody (CL488-67652) in Flow
1X10^6 A431 cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human TCF7L1/TCF7L2 (CL488-67652, Clone:2B2D12) (red), or 0.4 µg Mouse IgG2b Isotype Control (CL488-66360-3, Clone: K11B8C4B5) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL488-67652
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2B2D12
Immunogen
Recombinant protein
Conjugate
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MPQLGGGGGG GGGSGGGGGS SAGAAGGGDD LGANDELIPF QDEGGEEQEP SSDSASAQRD LDEVKSSLVN ESENQSSSSD SEAERRPQPV RDTFQKPRDY FAEVRRPQDS AFFKGPPYPG YPFLMIPDLS SPYLSNGPLS PGGARTYLQM KWPLLDVPSS ATVKDTRSPS PAHLSNKVPV VQHPHHMHPL TPLITYSNDH
Target Information
TCF7L1 is one of TCF/LEF transcription factors that are mediators of the Wnt signaling pathway and are antagonized by the TGF-beta signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It's necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. This antibody raised against 1-200aa of human TCF7L1 can also react with TCF7L2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: HMG box transcription factor 3; HMG box transcription factor 4; hTCF-4; mTCF-4; T-cell factor 3; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF-3; TCF7L1/2; transcription factor 3; Transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG box); transcription factor 7-like 1 (T-cell specific, HMG-box); Transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG box); transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box
Gene Aliases: bHLHb21; mTcf-4B; mTcf-4E; TCF-3; TCF-4; TCF3; TCF4; TCF4B; TCF4E; TCF7L1; TCF7L2
UniProt ID: (Human) Q9HCS4, (Human) Q9NQB0, (Mouse) Q9Z1J1, (Mouse) Q924A0
Entrez Gene ID: (Human) 83439, (Human) 6934, (Mouse) 21415, (Mouse) 21416
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support