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Proteintech
TCIRG1 Recombinant Rabbit Monoclonal Antibody (240166B2)
Product Details
83351-6-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
240166B2
Immunogen
TCIRG1 fusion protein Ag3378
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: CVSRLGELGL VEFRDLNASV SAFQRRFVVD VRRCEELEKT FTFLQEEVRR AGLVLPPPKG RLPAPPPRDL LRIQEETERL AQELRDVRGN QQALRAQLHQ LQLHAAVLRQ GHEPQLAAAH TDGASERTPL LQAPGGPHQD LRVNFVAGAV EPHKAPALER LLWRACRGFL IASFRELEQP LEHPVTGEPA TWMTFLISYW GEQIGQKIRK ITDCFHCHVF PFLQQEEARL GALQQLQQQS QELQEVLGET ERFLSQVLGR VLQLLPPGQV QVHKMKAVYL ALNQCSVSTT HKCLIAEAWC SVRDLPALQE ALRDSSMEEG VSAVAHRIPC RDMPPTLIRT NRFTASFQGI VDAYGVGRYQ EVNPAPYTII T
Target Information
The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase, H+ transporting, 116kD; OC-116 kDa; Osteoclastic proton pump 116 kDa subunit; specific 116-kDa vacuolar proton pump subunit; T-cell immune regulator 1; T-cell immune response cDNA 7; T-cell immune response cDNA7 protein; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3; TIRC7; V-ATPase 116 kDa subunit a 3; V-ATPase 116-kDa; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a 3; vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
Gene Aliases: a3; Atp6i; ATP6N1C; ATP6V0A3; OC-116kDa; OC116; OPTB1; Stv1; TCIRG1; TIRC7; Vph1
UniProt ID: (Human) Q13488
Entrez Gene ID: (Human) 10312
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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