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Invitrogen
TCR V beta 12 Monoclonal Antibody (S511)
Application
FIGURE: 1 / 1
TCR V beta 12 Antibody (TCR1654)
The specificity of anti-TCR V beta 12 (S511) monoclonal antibody (Product # TCR1654) was demonstrated by the flow cytometry detection of TCR V beta 12 on TCR V beta 12 positive PEER cells (left panel) compared to negative control HPB-ALL cells (right panel). {RE}
Product Details
TCR1654
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
S511
Immunogen
Human TCR V beta 12
Conjugate
Unconjugated
Form
Liquid
Concentration
0.15 mg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_417087
Product Specific Information
TCR1654 targets TCR V beta 12 in FACS, IHC(F), IP, and TCA applications and shows reactivity with Human samples.
The TCR1654 immunogen is human TCR V beta 12.
Target Information
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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