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Invitrogen
TCR gamma/delta Monoclonal Antibody (5A6.E9), FITC
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Application
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TCR gamma/delta Antibody (TCR2061) in Flow
Flow cytometry analysis of TCR gamma/delta on TCR gamma/delta positive PEER cells or TCR gamma/delta negative Jurkat cells. Equal numbers of cells were stained with a FITC-labeled TCR gamma + delta (5A6.E9) monoclonal antibody (Product # TCR2061) or were left unstained (black histograms). 5 µL of primary antibody were used per test. All antibody incubations were performed for 30 minutes at room temperature. A representative 10,000 cells were acquired for each sample.
Product Details
TCR2061
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5A6.E9
Immunogen
Pan TCR gamma delta
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.1% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_223620
Product Specific Information
TCR2061 targets TCR Pan TCR gamma delta in FACS applications and shows reactivity with Human samples.
The TCR2061 immunogen is pan TCR gamma delta.
TCR2061 detects TCR Pan TCR gamma delta which has a predicted molecular weight of approximately 18 kDa.
Target Information
TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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