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TERF1 Antibody (TA812205) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TERF1 (RC205904, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-TERF1. Positive lysates LY418833 (100 µg) and LC418833 (20 µg) can be purchased separately from OriGene.
Product Details
TA812205
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI3A1
Immunogen
Full length human recombinant protein of human TERF1 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ41416; NIMA-interacting protein 2; Telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; Telomeric repeat-binding factor 1; TTAGGG repeat-binding factor 1
Gene Aliases: hTRF1-AS; PIN2; t-TRF1; TERF1; TRBF1; TRF; TRF1
UniProt ID: (Human) Q93029
Entrez Gene ID: (Human) 7013
telomere maintenance
telomere maintenance via telomerase
mitotic nuclear division
negative regulation of DNA replication
telomere capping
telomeric loop formation
negative regulation of telomere maintenance via telomerase
negative regulation of telomere maintenance via semi-conservative replication
response to drug
meiotic telomere clustering
cell division
negative regulation of telomerase activity
positive regulation of telosome assembly
negative regulation of establishment of protein localization to telomere
negative regulation of establishment of RNA localization to telomere
negative regulation of establishment of macromolecular complex localization to telomere
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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