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TFAP2E is the sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 epsilon may play a role in the development of the CNS and in cartilage differentiation.
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Protein Aliases: AP-2-epsilon; MGC49007; Transcription factor AP-2-epsilon
Gene Aliases: tfap2e; zgc:65882; zgc:77338
UniProt ID: (Zebrafish) Q6P0E7
Entrez Gene ID: (Zebrafish) 393794
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