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Product Details
TA807912
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI3B4
Immunogen
Human recombinant protein fragment corresponding to amino acids 23-294 of human TGFBR2 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Transforming Growth Factor, beta receptor 2 (AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII) is a member of the TGF-beta family of receptor Serine/Threonine kinases. It is involved in the regulation of cell proliferation. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). TGFBR2 encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. TGFBR2 also has a pseudogene on chromosome 14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: tbetaR-II; tgf beta receptor 2; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta RII; TGFR-2; TGFR2; transforming growth factor beta receptor II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma; Transforming growth factor-beta receptor type II
Gene Aliases: AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TGFbeta-RII; TGFBR2; TGFR-2
UniProt ID: (Human) P37173
Entrez Gene ID: (Human) 7048
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type II
protein binding
ATP binding
glycosaminoglycan binding
mitogen-activated protein kinase kinase kinase binding
type I transforming growth factor beta receptor binding
SMAD binding
metal ion binding
transforming growth factor beta binding
serine/threonine protein kinase receptor
blood vessel development
patterning of blood vessels
vasculogenesis
in utero embryonic development
heart looping
positive regulation of mesenchymal cell proliferation
lens development in camera-type eye
positive regulation of tolerance induction to self antigen
positive regulation of B cell tolerance induction
positive regulation of T cell tolerance induction
outflow tract morphogenesis
growth plate cartilage chondrocyte growth
protein phosphorylation
receptor-mediated endocytosis
apoptotic process
transforming growth factor beta receptor signaling pathway
common-partner SMAD protein phosphorylation
Notch signaling pathway
smoothened signaling pathway
gastrulation
brain development
heart development
embryo implantation
aging
response to nutrient
positive regulation of cell proliferation
response to mechanical stimulus
response to glucose
regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of epithelial to mesenchymal transition
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
negative regulation of transforming growth factor beta receptor signaling pathway
organ regeneration
activation of protein kinase activity
embryonic hemopoiesis
wound healing
regulation of cell proliferation
response to drug
myeloid dendritic cell differentiation
positive regulation of skeletal muscle tissue regeneration
response to estrogen
positive regulation of angiogenesis
response to steroid hormone
digestive tract development
positive regulation of smooth muscle cell proliferation
embryonic cranial skeleton morphogenesis
positive regulation of NK T cell differentiation
palate development
negative regulation of cardiac muscle cell proliferation
pathway-restricted SMAD protein phosphorylation
ventricular septum morphogenesis
bronchus morphogenesis
trachea formation
mammary gland morphogenesis
lung lobe morphogenesis
response to cholesterol
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
lens fiber cell apoptotic process
positive regulation of reactive oxygen species metabolic process
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