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Peptide Sequence: LAVSVPAPTN VLSLSVCSMP LHSGQGEKPA APFPRGELES PKPLVTPGST LTLLTRAEAG SP
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 gene.
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Protein Aliases: 5'-TG-3' interacting factor 2; 5'-TG-3'-interacting factor 2; Homeobox protein TGIF2; OTTHUMP00000030849; TGF(beta)-induced transcription factor 2; TGF-beta-induced transcription factor 2; TGFB-induced factor 2; TGFB-induced factor 2 (TALE family homeobox); TGFB-induced factor homeobox 2; transcription growth factor-beta-induced factor 2
Gene Aliases: TGIF2
UniProt ID: (Human) Q9GZN2
Entrez Gene ID: (Human) 60436
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