Product References
Intestinal-mucosa anti-transglutaminase antibody assays to test for genetic gluten intolerance.
Cellular & molecular immunology
Quaglia S,De Leo L,Ziberna F,Vatta S,Villanacci V,Granzotto M,Petix V,Martelossi S,Di Leo G,Torelli L,Not T
MA5-12915 was used in immunohistochemistry to develop assays for the detection of genetic gluten intolerence based on the measurement of intestinal epithelial transglutaminase
Sat Nov 01 00:00:00 EDT 2014
TGM2: a cell surface marker in esophageal adenocarcinomas.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Leicht DT,Kausar T,Wang Z,Ferrer-Torres D,Wang TD,Thomas DG,Lin J,Chang AC,Lin L,Beer DG
MA5-12915 was used in immunohistochemistry and western blot to study the value of cell surface transglutaminase-2 as a biomarker for the early detection of esophageal adenocarcinomas
Sun Jun 01 00:00:00 EDT 2014
Transglutaminase 2 is essential for adherence of Porphyromonas gingivalis to host cells.
Proceedings of the National Academy of Sciences of the United States of America
Boisvert H,Lorand L,Duncan MJ
MA5-12915 was used in immunocytochemistry and western blot to study the role of cell-surface transglutaminase-2 in the host-cell adhesion of Porphyromonas gingivalis
Tue Apr 08 00:00:00 EDT 2014
Celiac disease patient IgA antibodies induce endothelial adhesion and cell polarization defects via extracellular transglutaminase 2.
Cellular and molecular life sciences : CMLS
Nadalutti CA,Korponay-Szabo IR,Kaukinen K,Griffin M,Mäki M,Lindfors K
MA5-12915 was used in ELISA and western blot to study the role of endothelial cell transglutaminase-2 secretion in the mechanism by which IgA antibodies from patients with celiac disease disrupt endothelial cell ahesion and polarization
Tue Apr 01 00:00:00 EDT 2014
Lack of transglutaminase 2 diminished T-cell responses in mice.
Immunology
Kim JH,Hong JM,Jeong EM,Lee WJ,Kim HR,Kang JS,Kim IG,Hwang YI
MA5-12915 was used in immunocytochemistry and western blot to study the role of transglutaminase-2 in murine T-cell responses
Tue Jul 01 00:00:00 EDT 2014
The kiwi fruit peptide kissper displays anti-inflammatory and anti-oxidant effects in in-vitro and ex-vivo human intestinal models.
Clinical and experimental immunology
Ciacci C,Russo I,Bucci C,Iovino P,Pellegrini L,Giangrieco I,Tamburrini M,Ciardiello MA
MA5-12915 was used in immunohistochemistry and western blot to use LPS-challenge to study the anti-inflammatory and anti-oxidant properties of the kissper peptide from Kiwi fruit in models of the human intestine
Sat Mar 01 00:00:00 EST 2014
Sampling of proximal and distal duodenal biopsies in the diagnosis and monitoring of celiac disease.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Caruso R,Marafini I,Del Vecchio Blanco G,Fina D,Paoluzi OA,Colantoni A,Sedda S,Pallone F,Monteleone G
MA5-12915 was used in immunohistochemistry to evaluate the ability to diagnose celiac disease using biopsy samples from the proximal and distal duodenum
Tue Apr 01 00:00:00 EDT 2014
Increased expression of transglutaminase 2 drives glycolytic metabolism in renal carcinoma cells.
Amino acids
Ku BM,Lee CH,Lee SH,Kim SY
MA5-12915 was used in immunocytochemistry and western blot to study the mechanism by which transglutaminase-2 expresson levels modulate glycolysis in renal carcinoma cells
Sun Jun 01 00:00:00 EDT 2014
Transglutaminase 2 and phospholipase A₂ interactions in the inflammatory response in human Thp-1 monocytes.
Amino acids
Currò M,Ferlazzo N,Risitano R,Condello S,Vecchio M,Caccamo D,Ientile R
MA5-12915 was used in immunoprecipitation and western blot to study inflammatory responses to LPS-stumulation of human THP-1 monocytes and the role of interactions between transglutaminase-2 and phospholipase A2
Sat Mar 01 00:00:00 EST 2014
Exercise, vascular stiffness, and tissue transglutaminase.
Journal of the American Heart Association
Steppan J,Sikka G,Jandu S,Barodka V,Halushka MK,Flavahan NA,Belkin AM,Nyhan D,Butlin M,Avolio A,Berkowitz DE,Santhanam L
MA5-12915 was used in immunohistochemistry to study the effects of aerobic exercise on NO signaling, transglutaminase-2 activity and vascular stiffness in a rat model
Thu Apr 10 00:00:00 EDT 2014
Gliadin does not induce mucosal inflammation or basophil activation in patients with nonceliac gluten sensitivity.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Bucci C,Zingone F,Russo I,Morra I,Tortora R,Pogna N,Scalia G,Iovino P,Ciacci C
MA5-12915 was used in immunohistochemistry to study whether gut mucosa from non-celiac patients with gluten-sensitivity displays inflammatory and immunological responses to gluten exposure
Tue Oct 01 00:00:00 EDT 2013
Protein kinase C delta is a substrate of tissue transglutaminase and a novel autoantigen in coeliac disease.
Clinical immunology (Orlando, Fla.)
Byrne G,Freeley M,Feighery C,Whelan A,Long A
MA5-12915 was used in western blot to study the occurrence of anti-PKC-delta autoantibodies in coeliac disease and the significance of tissue transglutaminase-catalysed PKC-delta transamidation and polymerization
Mon Apr 01 00:00:00 EDT 2013
Tissue transglutaminase mediates the pro-malignant effects of oncostatin M receptor over-expression in cervical squamous cell carcinoma.
The Journal of pathology
Caffarel MM,Chattopadhyay A,Araujo AM,Bauer J,Scarpini CG,Coleman N
MA5-12915 was used in immunohistochemistry to study the role of transglutaminase-2/integrin alpha5beta1 interactions in the pro-malignant activity of oncostatin M in cervical squamous carcinoma cells overexpressing the oncostatin M receptor
Tue Oct 01 00:00:00 EDT 2013
Garlic extract attenuating rat liver fibrosis by inhibiting TGF-β1.
Clinical nutrition (Edinburgh, Scotland)
D'Argenio G,Mazzone G,Ribecco MT,Lembo V,Vitaglione P,Guarino M,Morisco F,Napolitano M,Fogliano V,Caporaso N
MA5-12915 was used in western blot to study the role of TGF-beta downregulation in the mechanism by which a garlic extract protects against liver fibrosis
Mon Apr 01 00:00:00 EDT 2013
Transglutaminase 2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ku BM,Kim DS,Kim KH,Yoo BC,Kim SH,Gong YD,Kim SY
MA5-12915 was used in immunoprecipitation and western blot to study the mechanism by which inhibition of transglutaminase-2 promotes p53-dependent apoptosis in renal cell carcinoma
Sun Sep 01 00:00:00 EDT 2013
Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells.
Journal of immunology (Baltimore, Md. : 1950)
Iversen R,Di Niro R,Stamnaes J,Lundin KE,Wilson PC,Sollid LM
MA5-12915 was used in ELISA and flow cytometry to study N-terminal epitopes exposed only on soluble catalytically active transglutaminase-2 as the target of celiac disease auto-antibodies
Sat Jun 15 00:00:00 EDT 2013
Polymorphism of transglutaminase 2: unusually low frequency of genomic variants with deficient functions.
Amino acids
Király R,Barta E,Fésüs L
MA5-12915 was used in ELISA to study the effect of rare polymorphisms on the stability and function of transglutaminase-2
Tue Jan 01 00:00:00 EST 2013
Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA.
PloS one
Antonella Nadalutti C,Korponay-Szabo IR,Kaukinen K,Wang Z,Griffin M,Mäki M,Lindfors K
MA5-12915 was used in ELISA to study the ability of IgA from celiac disease patients to activate endothelial cell transglutaminase-2 and the mechanistic role of thioredoxin
Wed Jun 11 00:00:00 EDT 2014
Type 1 diabetes is associated with enterovirus infection in gut mucosa.
Diabetes
Oikarinen M,Tauriainen S,Oikarinen S,Honkanen T,Collin P,Rantala I,Mäki M,Kaukinen K,Hyöty H
MA5-12915 was used in immunohistochemistry to study the relationship between gut mucosal enterovirus infection and type I diabetes
Thu Mar 01 00:00:00 EST 2012
Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells.
Breast cancer research : BCR
Kumar A,Xu J,Sung B,Kumar S,Yu D,Aggarwal BB,Mehta K
MA5-12915 was used in immunocytochemistry and western blot to study the role of the transglutaminase-2 GTP-binding domain in promoting mammary epithelial cell epithelial-to-mesenchymal transition
Fri Jan 06 00:00:00 EST 2012
Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells.
Journal of cellular physiology
Zemskov EA,Mikhailenko I,Smith EP,Belkin AM
MA5-12915 was used in immunocytochemistry to study PDGF/PDGFR--driven signaling and phenotypic modulation of vascular smooth muscle cells and the role played by tissue transglutaminase
Tue May 01 00:00:00 EDT 2012
Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
D'Argenio G,Mazzone G,Tuccillo C,Ribecco MT,Graziani G,Gravina AG,Caserta S,Guido S,Fogliano V,Caporaso N,Romano M
MA5-12915 was used in western blot to study the effects of polyphenols extracted from apple on disease biomarkers and disease severity in a rat model of ulcerative colitis
Sun Jul 01 00:00:00 EDT 2012
Vena cava and aortic smooth muscle cells express transglutaminases 1 and 4 in addition to transglutaminase 2.
American journal of physiology. Heart and circulatory physiology
Johnson KB,Petersen-Jones H,Thompson JM,Hitomi K,Itoh M,Bakker EN,Johnson GV,Colak G,Watts SW
MA5-12915 was used in immunocytochemistry to study the expression of transglutaminases-1, -2 and -4 in the vena cava and aortic smooth muscle
Sun Apr 01 00:00:00 EDT 2012
Expression of tissue transglutaminase on primary olfactory ensheathing cells cultures exposed to stress conditions.
Neuroscience research
Campisi A,Spatuzza M,Russo A,Raciti G,Vanella A,Stanzani S,Pellitteri R
MA5-12915 was used in immunocytochemistry and western blot to study the effect of stress on the expression of transglutaminase-2 by olfactory ensheathing cells
Sun Apr 01 00:00:00 EDT 2012
Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression.
The Journal of biological chemistry
Ai L,Skehan RR,Saydi J,Lin T,Brown KD
MA5-12915 was used in western blot to study the molecular mechanisms regulating basal and DNA damage-induced transglutaminase-2 expression
Fri May 25 00:00:00 EDT 2012
Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.
Brain pathology (Zurich, Switzerland)
Wilhelmus MM,Verhaar R,Andringa G,Bol JG,Cras P,Shan L,Hoozemans JJ,Drukarch B
MA5-12915 was used in immunohistochemistry to study the presence of tissue transglutaminase in melanized neurons in Parkinson's disease brain
Tue Mar 01 00:00:00 EST 2011
Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease.
Neurochemistry international
Verhaar R,Jongenelen CA,Gerard M,Baekelandt V,Van Dam AM,Wilhelmus MM,Drukarch B
MA5-12915 was used in western blot to evaluate the efficacy of three tissue transglutaminase inhibitors and their effect on the transamidation of synuclein
Wed Jun 01 00:00:00 EDT 2011
Absence of mucosal inflammation in uncomplicated diverticular disease.
Digestive diseases and sciences
Elli L,Roncoroni L,Bardella MT,Terrani C,Bonura A,Ciulla M,Marconi S,Piodi L
MA5-12915 was used in immunohistochemistry to study the absence of mucosal inflammation in uncomplicated diverticular disease
Fri Jul 01 00:00:00 EDT 2011
Human tissue transglutaminase is inhibited by pharmacologic and chemical acetylation.
Protein science : a publication of the Protein Society
Lai TS,Davies C,Greenberg CS
MA5-12915 was used in western blot to study the effect of pharmacologic and chemical acetylation on tissue transglutaminase
Mon Feb 01 00:00:00 EST 2010
Transglutaminase 2 is involved in autophagosome maturation.
Autophagy
D'Eletto M,Farrace MG,Falasca L,Reali V,Oliverio S,Melino G,Griffin M,Fimia GM,Piacentini M
MA5-12915 was used in western blot to study the role of transglutaminase-2 in the maturation of autophagosomes using transgenic mice
Sun Nov 01 00:00:00 EDT 2009
Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain.
Brain pathology (Zurich, Switzerland)
Wilhelmus MM,Grunberg SC,Bol JG,van Dam AM,Hoozemans JJ,Rozemuller AJ,Drukarch B
MA5-12915 was used in immunohistochemistry to study the role of transglutaminases and transglutaminase-catalyzed cross-links in Alzheimer's disease pathology
Thu Oct 01 00:00:00 EDT 2009
Effects of post-translational modifications catalysed by pollen transglutaminase on the functional properties of microtubules and actin filaments.
The Biochemical journal
Del Duca S,Serafini-Fracassini D,Bonner P,Cresti M,Cai G
MA5-12915 was used in western blot to study the effect of pollen transglutaminase on the functional properties of microtubules and actin filaments
Sun Mar 15 00:00:00 EDT 2009
Positive auto-regulation of MYCN in human neuroblastoma.
Biochemical and biophysical research communications
Suenaga Y,Kaneko Y,Matsumoto D,Hossain MS,Ozaki T,Nakagawara A
MA5-12915 was used in western blot to study the auto-regulation of the MYCN oncogene in human neuroblastoma
Fri Dec 04 00:00:00 EST 2009
Protective effects of interrupting the binding of calmodulin to mutant huntingtin.
Journal of neuropathology and experimental neurology
Dudek NL,Dai Y,Muma NA
MA5-12915 was used in western blot to study the protective effects of disrupting the binding of calmodulin to mutant huntingtin
Tue Apr 01 00:00:00 EDT 2008
Type 2 transglutaminase differentially modulates striatal cell death in the presence of wild type or mutant huntingtin.
Journal of neurochemistry
Ruan Q,Quintanilla RA,Johnson GV
MA5-12915 was used in western blot to examine the role of type 2 transglutaminase in striatal cell death during the progression of Huntington disease
Sun Jul 01 00:00:00 EDT 2007
Cell-surface transglutaminase undergoes internalization and lysosomal degradation: an essential role for LRP1.
Journal of cell science
Zemskov EA,Mikhailenko I,Strickland DK,Belkin AM
MA5-12915 was used in ELISA to study the role of LRP1 in the internalization and lysosomal degradation of cell-surface transglutaminase
Sat Sep 15 00:00:00 EDT 2007
Transglutaminases: the missing link in nephrogenic systemic fibrosis.
The American Journal of dermatopathology
Parsons AC,Yosipovitch G,Sheehan DJ,Sangüeza OP,Greenberg CS,Sane DC
MA5-12915 was used in immunohistochemistry to investigate the role of transglutaminases in nephrogenic systemic fibrosis
Mon Oct 01 00:00:00 EDT 2007
Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation.
FEBS letters
Strnad P,Siegel M,Toivola DM,Choi K,Kosek JC,Khosla C,Omary MB
MA5-12915 was used in western blot to study the effect of transglutaminase inhibition on drug-primed liver hypertrophy and Mallory body formation
Mon Apr 17 00:00:00 EDT 2006
Long-term maintenance of human keratinocytes in vitro.
The Journal of investigative dermatology
Hasskarl J,Velupillai P,Piboonniyom SO,Grace M,Münger K
MA5-12915 was used in western blot to study the long-term maintenance of human keratinocytes in vitro
Tue Feb 01 00:00:00 EST 2005
Enhanced redundancy in Akt and mitogen-activated protein kinase-induced survival of malignant versus normal prostate epithelial cells.
Cancer research
Uzgare AR,Isaacs JT
MA5-12915 was used in western blot to study Akt and MAP kinase-induced survival of malignant versus normal prostate epithelial cells
Wed Sep 01 00:00:00 EDT 2004
Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells.
Archives of pharmacal research
Suh MD,Park CH,Kim SS,Kil MO,Lee GH,Johnson GV,Chun W
MA5-12915 was used in western blot to study whether tissue transglutaminase plays a role in alpha-synuclein aggregation in neuroblastoma cells
Sun Aug 01 00:00:00 EDT 2004
Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats.
Journal of neurochemistry
Lai TS,Tucker T,Burke JR,Strittmatter WJ,Greenberg CS
MA5-12915 was used in western blot to study the cross-linking of proteins with expanded polyglutamine repeats by tissue transglutaminase
Mon Mar 01 00:00:00 EST 2004
Increased expression of tissue-type transglutaminase following middle cerebral artery occlusion in rats.
Journal of neurochemistry
Tolentino PJ,Waghray A,Wang KK,Hayes RL
MA5-12915 was used in western blot to study the role of increased expression of tissue-type transglutaminase after middle cerebral artery occlusion in rats
Tue Jun 01 00:00:00 EDT 2004
Transglutaminase activity, protein, and mRNA expression are increased in progressive supranuclear palsy.
Journal of neuropathology and experimental neurology
Zemaitaitis MO,Kim SY,Halverson RA,Troncoso JC,Lee JM,Muma NA
MA5-12915 was used in western blot to study the role of increased transglutaminase expression in progressive supranuclear palsy
Sat Feb 01 00:00:00 EST 2003
Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes.
The Journal of biological chemistry
Ladd PA,Du L,Capdevila JH,Mernaugh R,Keeney DS
MA5-12915 was used in western blot to study the activation of transglutaminases by epoxyeicosatrienoic acids and its role in epidermal keratinocyte cornification
Fri Sep 12 00:00:00 EDT 2003
Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress.
Journal of neurochemistry
Piacentini M,Farrace MG,Piredda L,Matarrese P,Ciccosanti F,Falasca L,Rodolfo C,Giammarioli AM,Verderio E,Griffin M,Malorni W
MA5-12915 was used in western blot to study the mechanism by which tissue transglutaminase overexpression sensitizes neuronal cell lines to apoptosis
Sat Jun 01 00:00:00 EDT 2002
Up-regulation of tissue-type transglutaminase after traumatic brain injury.
Journal of neurochemistry
Tolentino PJ,DeFord SM,Notterpek L,Glenn CC,Pike BR,Wang KK,Hayes RL
MA5-12915 was used in western blot to study the increased expression of tissue transglutaminase in a rat model of traumatic brain injury
Fri Feb 01 00:00:00 EST 2002
Implication of tissue transglutaminase and desmoplakin in cell adhesion mechanism in human epidermis.
Molecular and cellular biochemistry
Esposito C,Lombardi ML,Ruocco V,Cozzolino A,Mariniello L,Porta R
MA5-12915 was used in immunohistochemistry to study the roles of tissue transglutaminase and desmoplakin in human epidermis cell adhesion
Wed Mar 01 00:00:00 EST 2000