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            • Primary Antibodies ›
            • TIM-3 Antibodies

            NeoBiotechnologies

            TIM3/HAVCR2/ CD366 (Effector T-Cell Marker) Monoclonal Antibody (TIM3/4025)

            View all (142) TIM-3 antibodies
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            Protocols
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            Catalog # 84868-MSM5-P0
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            Price (USD)
            302.00
             
            Estimated availability date: 20-May-2025
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            Cite TIM3/HAVCR2/ CD366 (Effector T-Cell Marker) Monoclonal Antibody (TIM3/4025)

            • Antibody Testing Data (5)
            Application
            TIM3/HAVCR2/ CD366 (Effector T-Cell Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Group 53 Created with Sketch.

            FIGURE: 1 / 5

            TIM3/HAVCR2/ CD366 (Effector T-Cell Marker) Antibody (84868-MSM5-P0) in IHC (P)

            Formalin-fixed, paraffin-embedded human lymph node stained with TIM3 Mouse Monoclonal Antibody (TIM3/4025).
            View Product

            TIM3/HAVCR2/ CD366 (Effector T-Cell Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            TIM3/HAVCR2/ CD366 (Effector T-Cell Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            TIM3/HAVCR2/ CD366 (Effector T-Cell Marker) Antibody in Western Blot (WB)
            TIM3/HAVCR2/ CD366 (Effector T-Cell Marker) Antibody in Peptide array (ARRAY)
            TIM3/HAVCR2/ CD366 (Effector T-Cell Marker) Antibody in SDS-PAGE (SDS-PAGE)

            Product Details

            84868-MSM5-P0

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1-2 µg/mL
            -

            Immunohistochemistry (Paraffin) (IHC (P))

            Assay-dependent
            -

            Immunohistochemistry (PFA fixed) (IHC (PFA))

            1-2 µg/mL
            -

            Peptide Array (Array)

            Assay-dependent
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Mouse / IgG2b, kappa

            Class

            Monoclonal

            Type

            Antibody

            Clone

            TIM3/4025

            Immunogen

            Recombinant fragment of human TIM3 protein (around aa 22-202).
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            200 µg/mL

            Purification

            Protein A/G

            Storage buffer

            PBS, pH 7.4, with 0.05% BSA

            Contains

            0.05% sodium azide

            Storage conditions

            4°C, do not freeze

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Target Information

            TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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            Cite this product

            Bioinformatics

            Protein Aliases: CD366; FLJ14428; HAVcr-2; Hepatitis A virus cellular receptor 2; kidney injury molecule-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM-3; TIMD-3

            View more View less

            Gene Aliases: CD366; HAVcr-2; HAVCR2; KIM-3; Tim-3; TIM3; TIMD-3; TIMD3

            View more View less

            UniProt ID: (Human) Q8TDQ0

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            Entrez Gene ID: (Human) 84868

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            Function(s)

            protein binding metal ion binding immunoglobulin receptor superfamily

            Process(es)

            adaptive immune response macrophage activation involved in immune response natural killer cell tolerance induction regulation of tolerance induction dependent upon immune response negative regulation of T-helper 1 type immune response negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target inflammatory response negative regulation of gene expression negative regulation of myeloid dendritic cell activation negative regulation of NF-kappaB transcription factor activity negative regulation of interferon-alpha production negative regulation of interferon-gamma production negative regulation of interleukin-2 production negative regulation of interleukin-3 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of chemokine production positive regulation of interferon-gamma production positive regulation of interleukin-1 production positive regulation of interleukin-4 production negative regulation of natural killer cell activation toll-like receptor 3 signaling pathway toll-like receptor 7 signaling pathway toll-like receptor 9 signaling pathway positive regulation of T cell proliferation negative regulation of T cell proliferation positive regulation of macrophage activation innate immune response defense response to Gram-positive bacterium maternal process involved in female pregnancy positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide negative regulation of granulocyte colony-stimulating factor production negative regulation of defense response to bacterium positive regulation of defense response to bacterium positive regulation of NIK/NF-kappaB signaling positive regulation of tumor necrosis factor secretion negative regulation of immunological synapse formation negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
            It has to be done as per old AB suggested Products section.
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