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Immunogen sequence: PVTGSSSGL LALGALGSQA HLTVKDEKNH HELDHRERES SANNSVSPSE SLRASEKHRG SADYSMEAKK RKAEEKDSLS RYDS (158-240 aa encoded by B C015729)
The TLE genes are differentially expressed and encode nuclear proteins, consistent with the presence of sequence motifs associated with nuclear functions. These genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway which controls a number of different cell-fate choices in invertebrates and vertebrates.
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Protein Aliases: enhancer of split groucho 3; Enhancer of split groucho-like protein 3; ESG; ESG-1; ESG-2; ESG-3; ESG-4; ESG3; Grg-3; rTLE3; Tle1; Tle2; tle4; transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 3 homolog of Drosophila; transducin-like enhancer of split 3 short isoform; transducin-like enhancer of split 3, E(spl) homolog; transducin-like enhancer of split 3, homolog of Drosophila E(sp1); transducin-like enhancer of split 3, homolog of Drosophila E(spl); Transducin-like enhancer protein 3
Gene Aliases: 2610103N05Rik; ESG; ESG3; Esp3; GRG3; Grg3a; Grg3b; HsT18976; KIAA1547; mKIAA1547; TLE3
UniProt ID: (Human) Q04726, (Mouse) Q08122, (Rat) Q9JIT3
Entrez Gene ID: (Human) 7090, (Mouse) 21887, (Rat) 84424
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