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Immunogen sequence: MYPQGRHPA PHQPGQPGFK FTVAESCDRI KDEFQFLQAQ YHSLKVEYDK LANEKTEMQR HYVMYYEMSY GLNIEMHKQT EIAKRLNTIL AQIMPFLSQE HQQQVAQAVE RAKQVTMTEL NAIIGQQQLQ AQHLSHATHG PPVQLPPHPS GLQPPGIPPV TGSSSGLLAL GALGSQAHLT VKDEKNHHEL DHRERESSAN NSVSPSESLR ASEKHRGSAD YSMEAKKRKA EEKDSLSRYD SDGDKSDDLV VDVSNEDPAT PRVSPAHSPP ENGLDKARSL KKDAPTSPAS VASSSSTPSS KTKDLGHNDK SSTPGLKSNT PTPRNDAPTP GTSTTPGLRS MPGKPPGMDP I
The TLE genes are differentially expressed and encode nuclear proteins, consistent with the presence of sequence motifs associated with nuclear functions. These genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway which controls a number of different cell-fate choices in invertebrates and vertebrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: enhancer of split groucho 3; Enhancer of split groucho-like protein 3; ESG-1; ESG-2; ESG-3; ESG-4; ESG3; Tle1; Tle2; tle4; transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 3 short isoform; transducin-like enhancer of split 3, homolog of Drosophila E(sp1); Transducin-like enhancer protein 3
Gene Aliases: ESG; ESG3; GRG3; HsT18976; KIAA1547; TLE3
UniProt ID: (Human) Q04726
Entrez Gene ID: (Human) 7090
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