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Product Details
BS-7551R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TNFAIP3 interacting protein 3/ABIN3, amino acids 51-150.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTU domain-containing protein 7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha-induced protein 3; TNFAIP3 (A20); Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; Zinc finger protein A20
Gene Aliases: A20; AISBL; OTUD7C; TNFA1P2; TNFAIP3; Tnfip3
UniProt ID: (Human) P21580, (Mouse) Q60769
Entrez Gene ID: (Human) 7128, (Rat) 683206, (Mouse) 21929
protease binding
DNA binding
ubiquitin-protein transferase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
zinc ion binding
ligase activity
kinase binding
ubiquitin binding
protein self-association
K63-linked polyubiquitin binding
catalytic activity
peptidase activity
cysteine-type peptidase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
hydrolase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
cysteine protease
B-1 B cell homeostasis
response to molecule of bacterial origin
regulation of germinal center formation
negative regulation of chronic inflammatory response
apoptotic process
inflammatory response
regulation of tumor necrosis factor-mediated signaling pathway
protein deubiquitination
negative regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
response to muramyl dipeptide
negative regulation of interleukin-1 beta production
negative regulation of interleukin-2 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor 2 signaling pathway
negative regulation of toll-like receptor 3 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
negative regulation of toll-like receptor 5 signaling pathway
protein K11-linked deubiquitination
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of protein catabolic process
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of bone resorption
negative regulation of innate immune response
negative regulation of smooth muscle cell proliferation
regulation of defense response to virus by host
regulation of inflammatory response
negative regulation of inflammatory response
negative regulation of B cell activation
protein oligomerization
regulation of vascular wound healing
cellular response to hydrogen peroxide
nucleotide-binding oligomerization domain containing signaling pathway
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
protein K63-linked deubiquitination
protein K48-linked ubiquitination
protein K48-linked deubiquitination
cellular response to lipopolysaccharide
protein deubiquitination involved in ubiquitin-dependent protein catabolic process
tolerance induction to lipopolysaccharide
establishment of protein localization to vacuole
negative regulation of osteoclast proliferation
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of cellular protein catabolic process
positive regulation of hepatocyte proliferation
negative regulation of CD40 signaling pathway
negative regulation of endothelial cell apoptotic process
negative regulation of cell death
marginal zone B cell differentiation
negative regulation of granuloma formation
regulation of immunoglobulin production
proteolysis
metabolic process
response to wounding
negative regulation of autophagy
negative regulation of heterotypic cell-cell adhesion
regulation of innate immune response
Performance Guarantee
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