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Product Details
PA5-120358
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 345-455 of human TNFR1/TNFRSF1A (NP_001056.1).
Conjugate
Form
Liquid
Concentration
2.97 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2913930
Product Specific Information
Positive test controls include: A-549, Rat kidney. The target is usually found in the following locations: Cell membrane, Golgi apparatus membrane, Secreted, Secreted, Single-pass type I membrane protein.
Immunogen sequence: AHKPQSLDTD DPATLYAVVE NVPPLRWKEF VRRLGLSDHE IDRLELQNGR CLREAQYSML ATWRRRTPRR EATLELLGRV LRDMDLLGCL EDIEEALCGP AALPPAPSLL R
Target Information
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD120a; CD120a antigen; MGC19588; n-smase activation assoc. factor; p55; p60; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TNF receptor alpha chain; TNF-alpha-R1; TNF-R1; TNF-RI; TNFR; TNFR I; TNFR-I; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor; Tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; Tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor
Gene Aliases: CD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR; TNFR-1; Tnfr-2; TNFR1; TNFR1-d2; TNFR55; TNFR60; TNFRI; TNFRp55; TNFRSF1A
UniProt ID: (Human) P19438, (Rat) P22934, (Mouse) P25118
Entrez Gene ID: (Human) 7132, (Rat) 25625, (Mouse) 21937
prostaglandin metabolic process
inflammatory response
immune response
I-kappaB kinase/NF-kappaB signaling
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of tumor necrosis factor-mediated signaling pathway
viral process
cytokine-mediated signaling pathway
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
positive regulation of tyrosine phosphorylation of Stat1 protein
defense response to bacterium
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
negative regulation of inflammatory response
positive regulation of inflammatory response
cellular response to mechanical stimulus
death-inducing signaling complex assembly
establishment of protein localization to plasma membrane
regulation of establishment of endothelial barrier
positive regulation of ceramide biosynthetic process
response to hypoxia
defense response
cell surface receptor signaling pathway
response to wounding
positive regulation of gene expression
negative regulation of gene expression
programmed cell death
negative regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
tetrapyrrole metabolic process
positive regulation of protein import into nucleus, translocation
negative regulation of apoptotic process
response to amino acid
response to alkaloid
positive regulation of neuron apoptotic process
response to ethanol
positive regulation of angiogenesis
protein heterooligomerization
cellular response to estradiol stimulus
apoptotic process
signal transduction
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