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NeoBiotechnologies
TPO (Thyroid Peroxidase) (Thyroid Marker) Recombinant Rabbit Monoclonal Antibody (TPO/3813R)
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Product Details
7173-RBM13-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
TPO/3813R
Immunogen
Recombinant fragment of human TPO (around aa 685-804).
Conjugate
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Thyroid Peroxidase is a gene that encodes for a membrane-bound glycoprotein, which functions as an enzyme and plays a crucial role in the proper functioning of the thyroid gland. This protein is responsible for the iodination of tyrosine residues in thyroglobulin and the formation of phenoxy-ester between pairs of iodinated tyrosines, which leads to the production of thyroid hormones such as thyroxine and triiodothyronine. Mutations in this gene are known to cause several disorders related to thyroid hormone production, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Several transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants remains undetermined. Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 1.11.1; thyroid microsomal antigen; Thyroid peroxidase; thyroperoxidase; TPO; TPXEC 1.11.1.8
Gene Aliases: MSA; TDH2A; TPO; TPX
UniProt ID: (Human) P07202
Entrez Gene ID: (Human) 7173
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