Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
Immunogen sequence: MGSVLSTDSG KSAPASATAR ALERRRDPEL PVTSFDCAVC LEVLHQPVRT RCGHVFCRSC IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYKNC AECDT; Positive Samples: Raji, K-562
TRAC-1 is a 232 amino acid protein containing an N-terminal RING-type zinc finger domain. It functions as a positive regulator in the T-cell receptor signaling pathway, thus leading to T-cell activation. It mediates ubiquitination and subsequent proteasomal degradation of target proteins. TRAC-1 is expressed in lymphoid tissues, including bone marrow, spleen, thymus as well as in other tissues. It is predominantly expressed in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase RNF125; RING finger protein 125; ring finger protein 125, E3 ubiquitin protein ligase; T-cell RING activation protein 1; T-cell ring protein identified in activation screen; TRAC-1
Gene Aliases: RNF125; TNORS; TRAC-1; TRAC1
UniProt ID: (Human) Q96EQ8
Entrez Gene ID: (Human) 54941
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support