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Peptide Sequence: FCQRELYEDS LLDHCITHHR SERRPVFCPL CRLIPDENPS SFSGSLIRHL QVSHTLFYDD FIDFNIIEEA LIRRVLDRSL LEYVNHSNT
TRAC-1 is a 232 amino acid protein containing an N-terminal RING-type zinc finger domain. It functions as a positive regulator in the T-cell receptor signaling pathway, thus leading to T-cell activation. It mediates ubiquitination and subsequent proteasomal degradation of target proteins. TRAC-1 is expressed in lymphoid tissues, including bone marrow, spleen, thymus as well as in other tissues. It is predominantly expressed in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase RNF125; RING finger protein 125; ring finger protein 125, E3 ubiquitin protein ligase; T-cell RING activation protein 1; T-cell ring protein identified in activation screen; TRAC-1
Gene Aliases: RNF125; TNORS; TRAC-1; TRAC1
UniProt ID: (Human) Q96EQ8
Entrez Gene ID: (Human) 54941
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