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TRIM21 Polyclonal Antibody

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Antibody Testing Data (13)

TRIM21 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 13

TRIM21 Antibody (12108-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed A549 cells using 12108-1-AP (TRIM21 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

TRIM21 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TRIM21 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12108-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 35 publications 35 publications

Immunohistochemistry (IHC)

View 11 publications 11 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 11 publications 11 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 15 publications 15 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Hamster, Human, Mouse, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TRIM21 Fusion Protein Ag2753 (176-475 aa encoded by BC010861)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SRIHAEFVQ QKNFLVEEEQ RQLQELEKDE REQLRILGEK EAKLAQQSQA LQELISELDR RCHSSALELL QEVIIVLERS ESWNLKDLDI TSPELRSVCH VPGLKKMLRT CAVHITLDPD TANPWLILSE DRRQVRLGDT QQSIPGNEER FDSYPMVLGA QHFHSGKHYW EVDVTGKEAW DLGVCRDSVR RKGHFLLSSK SGFWTIWLWN KQKYEAGTYP QTPLHLQVPP CQVGIFLDYE AGMVSFYNIT DHGSLIYSFS ECAFTGPLRP FFSPGFNDGG KNTAPLTLCP LNIGSQGSTD Y (176-475 aa encoded by BC010861)

Target Information

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.

Journal of experimental & clinical cancer research : CR

Chen X,Yong H,Chen M,Deng C,Wang P,Chu S,Li M,Hou P,Zheng J,Li Z,Bai J

Wed Jan 25 00:00:00 EST 2023

TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.

Journal of experimental & clinical cancer research : CR

Chen X,Yong H,Chen M,Deng C,Wang P,Chu S,Li M,Hou P,Zheng J,Li Z,Bai J

Wed Jan 25 00:00:00 EST 2023

TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.

Journal of experimental & clinical cancer research : CR

Chen X,Yong H,Chen M,Deng C,Wang P,Chu S,Li M,Hou P,Zheng J,Li Z,Bai J

Wed Jan 25 00:00:00 EST 2023

TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.

Journal of experimental & clinical cancer research : CR

Chen X,Yong H,Chen M,Deng C,Wang P,Chu S,Li M,Hou P,Zheng J,Li Z,Bai J

Wed Jan 25 00:00:00 EST 2023

TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.

Journal of experimental & clinical cancer research : CR

Chen X,Yong H,Chen M,Deng C,Wang P,Chu S,Li M,Hou P,Zheng J,Li Z,Bai J

Wed Jan 25 00:00:00 EST 2023

TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.

Journal of experimental & clinical cancer research : CR

Chen X,Yong H,Chen M,Deng C,Wang P,Chu S,Li M,Hou P,Zheng J,Li Z,Bai J

Wed Jan 25 00:00:00 EST 2023

Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells.

Chemico-biological interactions

Gui Z,Li J,Li J,Li X,Chen L,Ma Z,Tang X,Gong X,Chai X,Lu F,Li M,Ma H,Li X,Ye X

Sat Apr 01 00:00:00 EDT 2023

Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells.

Chemico-biological interactions

Gui Z,Li J,Li J,Li X,Chen L,Ma Z,Tang X,Gong X,Chai X,Lu F,Li M,Ma H,Li X,Ye X

Sat Apr 01 00:00:00 EDT 2023

Mechanism of action of IC 100, a humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC).

Translational research : the journal of laboratory and clinical medicine

de Rivero Vaccari JP,Mim C,Hadad R,Cyr B,Stefansdottir TA,Keane RW

Sun Jan 01 00:00:00 EST 2023

TRIM21 promotes inflammation by ubiquitylating NF-κB in T cells of oral lichen planus.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Yao Y,Pan L,Wei Y,Feng M,Li X,Sun L,Tang G,Wang Y

Mon May 01 00:00:00 EDT 2023

TRIM21 promotes inflammation by ubiquitylating NF-κB in T cells of oral lichen planus.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Yao Y,Pan L,Wei Y,Feng M,Li X,Sun L,Tang G,Wang Y

Mon May 01 00:00:00 EDT 2023

TRIM21 promotes inflammation by ubiquitylating NF-κB in T cells of oral lichen planus.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Yao Y,Pan L,Wei Y,Feng M,Li X,Sun L,Tang G,Wang Y

Mon May 01 00:00:00 EDT 2023

TRIM21 promotes inflammation by ubiquitylating NF-κB in T cells of oral lichen planus.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Yao Y,Pan L,Wei Y,Feng M,Li X,Sun L,Tang G,Wang Y

Mon May 01 00:00:00 EDT 2023

The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer.

The Journal of clinical investigation

Liu J,Zhang C,Xu D,Zhang T,Chang CY,Wang J,Liu J,Zhang L,Haffty BG,Zong WX,Hu W,Feng Z

Wed Mar 15 00:00:00 EDT 2023

TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury.

Life sciences

Sun X,Huang N,Li P,Dong X,Yang J,Zhang X,Zong WX,Gao S,Xin H

Mon May 15 00:00:00 EDT 2023

TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury.

Life sciences

Sun X,Huang N,Li P,Dong X,Yang J,Zhang X,Zong WX,Gao S,Xin H

Mon May 15 00:00:00 EDT 2023

TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury.

Life sciences

Sun X,Huang N,Li P,Dong X,Yang J,Zhang X,Zong WX,Gao S,Xin H

Mon May 15 00:00:00 EDT 2023

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

Cellular and molecular life sciences : CMLS

Zhang K,Yang C,Zhou X,Liang J,Guo J,Li M,Zhang Y,Shao S,Sun P,Li K,Huang J,Chen F,Liang X,Su D

Tue May 30 00:00:00 EDT 2023

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

Cellular and molecular life sciences : CMLS

Zhang K,Yang C,Zhou X,Liang J,Guo J,Li M,Zhang Y,Shao S,Sun P,Li K,Huang J,Chen F,Liang X,Su D

Tue May 30 00:00:00 EDT 2023

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

Cellular and molecular life sciences : CMLS

Zhang K,Yang C,Zhou X,Liang J,Guo J,Li M,Zhang Y,Shao S,Sun P,Li K,Huang J,Chen F,Liang X,Su D

Tue May 30 00:00:00 EDT 2023

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

Cellular and molecular life sciences : CMLS

Zhang K,Yang C,Zhou X,Liang J,Guo J,Li M,Zhang Y,Shao S,Sun P,Li K,Huang J,Chen F,Liang X,Su D

Tue May 30 00:00:00 EDT 2023

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

Cellular and molecular life sciences : CMLS

Zhang K,Yang C,Zhou X,Liang J,Guo J,Li M,Zhang Y,Shao S,Sun P,Li K,Huang J,Chen F,Liang X,Su D

Tue May 30 00:00:00 EDT 2023

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

Cellular and molecular life sciences : CMLS

Zhang K,Yang C,Zhou X,Liang J,Guo J,Li M,Zhang Y,Shao S,Sun P,Li K,Huang J,Chen F,Liang X,Su D

Tue May 30 00:00:00 EDT 2023

Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.

Autophagy

Yang C,Wang Z,Kang Y,Yi Q,Wang T,Bai Y,Liu Y

Sat Jul 01 00:00:00 EDT 2023

HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.

Cancer letters

Sun X,Zhang K,Peng X,Zhou P,Qu C,Yang L,Shen L

Sun May 28 00:00:00 EDT 2023

HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.

Cancer letters

Sun X,Zhang K,Peng X,Zhou P,Qu C,Yang L,Shen L

Sun May 28 00:00:00 EDT 2023

UBE2L3 Reduces TRIM21 Expression and IL-1β Secretion in Epidermal Keratinocytes and Improves Psoriasis-Like Skin.

The Journal of investigative dermatology

Chen XY,Xu F,Chen JQ,Landeck L,Chen SQ,Zhou Y,Wang Z,Fu NC,Zheng M,Zhang X,Man XY

Mon May 01 00:00:00 EDT 2023

Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity.

Science advances

Fu Z,Chen S,Zhu Y,Zhang D,Xie P,Jiao Q,Chi J,Xu S,Xue Y,Lu X,Song X,Cristofanilli M,Gradishar WJ,Kalinsky K,Yin Y,Zhang B,Wan Y

Fri Jan 06 00:00:00 EST 2023

Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity.

Science advances

Fu Z,Chen S,Zhu Y,Zhang D,Xie P,Jiao Q,Chi J,Xu S,Xue Y,Lu X,Song X,Cristofanilli M,Gradishar WJ,Kalinsky K,Yin Y,Zhang B,Wan Y

Fri Jan 06 00:00:00 EST 2023

Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity.

Science advances

Fu Z,Chen S,Zhu Y,Zhang D,Xie P,Jiao Q,Chi J,Xu S,Xue Y,Lu X,Song X,Cristofanilli M,Gradishar WJ,Kalinsky K,Yin Y,Zhang B,Wan Y

Fri Jan 06 00:00:00 EST 2023

AGO4 suppresses tumor growth by modulating autophagy and apoptosis via enhancing TRIM21-mediated ubiquitination of GRP78 in a p53-independent manner.

Oncogene

Wang L,Li D,Su X,Zhao Y,Huang A,Li H,Li J,Xia W,Jia T,Zhang H,Dong J,Liu X,Shao N

Sun Jan 01 00:00:00 EST 2023

AGO4 suppresses tumor growth by modulating autophagy and apoptosis via enhancing TRIM21-mediated ubiquitination of GRP78 in a p53-independent manner.

Oncogene

Wang L,Li D,Su X,Zhao Y,Huang A,Li H,Li J,Xia W,Jia T,Zhang H,Dong J,Liu X,Shao N

Sun Jan 01 00:00:00 EST 2023

AGO4 suppresses tumor growth by modulating autophagy and apoptosis via enhancing TRIM21-mediated ubiquitination of GRP78 in a p53-independent manner.

Oncogene

Wang L,Li D,Su X,Zhao Y,Huang A,Li H,Li J,Xia W,Jia T,Zhang H,Dong J,Liu X,Shao N

Sun Jan 01 00:00:00 EST 2023

Quantitative interactome proteomics identifies a proteostasis network for GABA_A receptors.

The Journal of biological chemistry

Wang YJ,Di XJ,Mu TW

Sat Oct 01 00:00:00 EDT 2022

Quantitative interactome proteomics identifies a proteostasis network for GABA_A receptors.

The Journal of biological chemistry

Wang YJ,Di XJ,Mu TW

Sat Oct 01 00:00:00 EDT 2022

Quantitative interactome proteomics identifies a proteostasis network for GABA_A receptors.

The Journal of biological chemistry

Wang YJ,Di XJ,Mu TW

Sat Oct 01 00:00:00 EDT 2022

Quantitative interactome proteomics identifies a proteostasis network for GABA_A receptors.

The Journal of biological chemistry

Wang YJ,Di XJ,Mu TW

Sat Oct 01 00:00:00 EDT 2022

MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.

Cell communication and signaling : CCS

Wen P,Wang H,Li Y,Sui X,Hou Z,Guo X,Xue W,Liu D,Wang Y,Gao J

Fri Oct 28 00:00:00 EDT 2022

MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.

Cell communication and signaling : CCS

Wen P,Wang H,Li Y,Sui X,Hou Z,Guo X,Xue W,Liu D,Wang Y,Gao J

Fri Oct 28 00:00:00 EDT 2022

MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.

Cell communication and signaling : CCS

Wen P,Wang H,Li Y,Sui X,Hou Z,Guo X,Xue W,Liu D,Wang Y,Gao J

Fri Oct 28 00:00:00 EDT 2022

TRIM21‑a potential biomarker for the prognosis of thyroid cancer.

Experimental and therapeutic medicine

Wu Z,Wang Y,Yu Z,Meng Z,Duan W,Zhang W,Fang J

Thu Dec 01 00:00:00 EST 2022

Porcine TRIM21 Enhances Porcine Circovirus 2 Infection and Host Immune Responses, But Inhibits Apoptosis of PCV2-Infected Cells.

Viruses

Yang L,Liu X,Zhang L,Li X,Zhang X,Niu G,Ji W,Chen S,Ouyang H,Ren L

Sat Jan 15 00:00:00 EST 2022

Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.

The Journal of nutritional biochemistry

Qi H,Wang L,Zhang M,Wang Z,Gao X,Li M

Tue Mar 01 00:00:00 EST 2022

Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.

Nature communications

Zhang J,Gan Y,Li H,Yin J,He X,Lin L,Xu S,Fang Z,Kim BW,Gao L,Ding L,Zhang E,Ma X,Li J,Li L,Xu Y,Horne D,Xu R,Yu H,Gu Y,Huang W

Fri May 20 00:00:00 EDT 2022

Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.

Nature communications

Zhang J,Gan Y,Li H,Yin J,He X,Lin L,Xu S,Fang Z,Kim BW,Gao L,Ding L,Zhang E,Ma X,Li J,Li L,Xu Y,Horne D,Xu R,Yu H,Gu Y,Huang W

Fri May 20 00:00:00 EDT 2022

Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus.

JCI insight

Gomez-Bañuelos E,Wahadat MJ,Li J,Paz M,Antiochos B,Celia AI,Andrade V,Ferris DP,Goldman DW,Darrah E,Petri M,Andrade F

Mon Oct 10 00:00:00 EDT 2022

TRIM18 is a critical regulator of viral myocarditis and organ inflammation.

Journal of biomedical science

Fang M,Zhang A,Du Y,Lu W,Wang J,Minze LJ,Cox TC,Li XC,Xing J,Zhang Z

Sun Jul 31 00:00:00 EDT 2022

Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-κB p65 subunit and promotes inflammation in keratinocytes.

The British journal of dermatology

Yang L,Zhang T,Zhang C,Xiao C,Bai X,Wang G

Fri Jan 01 00:00:00 EST 2021

Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-κB p65 subunit and promotes inflammation in keratinocytes.

The British journal of dermatology

Yang L,Zhang T,Zhang C,Xiao C,Bai X,Wang G

Fri Jan 01 00:00:00 EST 2021

Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-κB p65 subunit and promotes inflammation in keratinocytes.

The British journal of dermatology

Yang L,Zhang T,Zhang C,Xiao C,Bai X,Wang G

Fri Jan 01 00:00:00 EST 2021

African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3.

Frontiers in cellular and infection microbiology

Wang Y,Cui S,Xin T,Wang X,Yu H,Chen S,Jiang Y,Gao X,Jiang Y,Guo X,Jia H,Zhu H

Tue Apr 05 00:00:00 EDT 2022

African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3.

Frontiers in cellular and infection microbiology

Wang Y,Cui S,Xin T,Wang X,Yu H,Chen S,Jiang Y,Gao X,Jiang Y,Guo X,Jia H,Zhu H

Tue Apr 05 00:00:00 EDT 2022

WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.

Oral oncology

Zhao Y,Li WF,Li QJ,He SW,He QM,Long LF,Liu N,Ma J

Mon Nov 01 00:00:00 EDT 2021

WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.

Oral oncology

Zhao Y,Li WF,Li QJ,He SW,He QM,Long LF,Liu N,Ma J

Mon Nov 01 00:00:00 EDT 2021

WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.

Oral oncology

Zhao Y,Li WF,Li QJ,He SW,He QM,Long LF,Liu N,Ma J

Mon Nov 01 00:00:00 EDT 2021

Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3C^pro.

Virologica Sinica

Xiao H,Li J,Yang X,Li Z,Wang Y,Rui Y,Liu B,Zhang W

Wed Dec 01 00:00:00 EST 2021

MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.

EMBO reports

Tan CT,Chang HC,Zhou Q,Yu C,Fu NY,Sabapathy K,Yu VC

Thu Jan 07 00:00:00 EST 2021

The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.

Cellular and molecular gastroenterology and hepatology

Wang F,Zhang Y,Shen J,Yang B,Dai W,Yan J,Maimouni S,Daguplo HQ,Coppola S,Gao Y,Wang Y,Du Z,Peng K,Liu H,Zhang Q,Tang F,Wang P,Gao S,Wang Y,Ding WX,Guo G,Wang F,Zong WX

Tue Mar 08 00:00:00 EST 2022

The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.

Cellular and molecular gastroenterology and hepatology

Wang F,Zhang Y,Shen J,Yang B,Dai W,Yan J,Maimouni S,Daguplo HQ,Coppola S,Gao Y,Wang Y,Du Z,Peng K,Liu H,Zhang Q,Tang F,Wang P,Gao S,Wang Y,Ding WX,Guo G,Wang F,Zong WX

Tue Mar 08 00:00:00 EST 2022

The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.

Cellular and molecular gastroenterology and hepatology

Wang F,Zhang Y,Shen J,Yang B,Dai W,Yan J,Maimouni S,Daguplo HQ,Coppola S,Gao Y,Wang Y,Du Z,Peng K,Liu H,Zhang Q,Tang F,Wang P,Gao S,Wang Y,Ding WX,Guo G,Wang F,Zong WX

Tue Mar 08 00:00:00 EST 2022

The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.

Cellular and molecular gastroenterology and hepatology

Wang F,Zhang Y,Shen J,Yang B,Dai W,Yan J,Maimouni S,Daguplo HQ,Coppola S,Gao Y,Wang Y,Du Z,Peng K,Liu H,Zhang Q,Tang F,Wang P,Gao S,Wang Y,Ding WX,Guo G,Wang F,Zong WX

Tue Mar 08 00:00:00 EST 2022

Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape.

Frontiers in cell and developmental biology

Yao L,Xu L,Zhou L,Wu S,Zou W,Chen M,Chen J,Peng H

Tue Jun 15 00:00:00 EDT 2021

Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape.

Frontiers in cell and developmental biology

Yao L,Xu L,Zhou L,Wu S,Zou W,Chen M,Chen J,Peng H

Tue Jun 15 00:00:00 EDT 2021

Porcine TRIM21 RING-finger E3 ubiquitin ligase is essential for anti-PRRSV activity.

Veterinary microbiology

Wei Y,Zeng S,Zou C,Zhang H,Peng O,Xue C,Cao Y

Sat May 01 00:00:00 EDT 2021

Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA_A R-Dependent TRIM21 Modulation of Src Expression.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Liu Q,Sheng Z,Cheng C,Zheng H,Lanuti M,Liu R,Wang P,Shen Y,Xie Z

Wed Sep 01 00:00:00 EDT 2021

Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA_A R-Dependent TRIM21 Modulation of Src Expression.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Liu Q,Sheng Z,Cheng C,Zheng H,Lanuti M,Liu R,Wang P,Shen Y,Xie Z

Wed Sep 01 00:00:00 EDT 2021

Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA_A R-Dependent TRIM21 Modulation of Src Expression.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Liu Q,Sheng Z,Cheng C,Zheng H,Lanuti M,Liu R,Wang P,Shen Y,Xie Z

Wed Sep 01 00:00:00 EDT 2021

Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma.

Translational oncology

Gao L,Xia L,Ji W,Zhang Y,Xia W,Lu S

Wed Sep 01 00:00:00 EDT 2021

Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting.

Cell death & disease

Jin J,Meng X,Huo Y,Deng H

Tue Jul 13 00:00:00 EDT 2021

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein.

Proceedings of the National Academy of Sciences of the United States of America

Hsu JC,Laurent-Rolle M,Pawlak JB,Wilen CB,Cresswell P

Tue Jun 15 00:00:00 EDT 2021

TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.

EMBO reports

Li Z,Huan C,Wang H,Liu Y,Liu X,Su X,Yu J,Zhao Z,Yu XF,Zheng B,Zhang W

Tue Jan 07 00:00:00 EST 2020

TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.

EMBO reports

Li Z,Huan C,Wang H,Liu Y,Liu X,Su X,Yu J,Zhao Z,Yu XF,Zheng B,Zhang W

Tue Jan 07 00:00:00 EST 2020

Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.

Neurochemical research

Liu XF,Tang CX,Zhang L,Tong SY,Wang Y,Abdulrahman AA,Ji GQ,Gao Y,Gao DS,Zhang BL

Tue Dec 01 00:00:00 EST 2020

Enhanced T-cell proliferation and IL-6 secretion mediated by overexpression of TRIM21 in oral lesions of patients with oral lichen planus.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Wei W,Wang Y,Sun Q,Jiang C,Zhu M,Song C,Li C,Du G,Deng Y,Nie H,Tang G

Wed Apr 01 00:00:00 EDT 2020

TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis.

Journal of biomedical science

Zhang P,Li X,He Q,Zhang L,Song K,Yang X,He Q,Wang Y,Hong X,Ma J,Liu N

Fri Jan 31 00:00:00 EST 2020

UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.

Journal of experimental & clinical cancer research : CR

Sun J,Zhu Z,Li W,Shen M,Cao C,Sun Q,Guo Z,Liu L,Wu D

Wed Oct 21 00:00:00 EDT 2020

TRIM21 Mitigates Human Lung Microvascular Endothelial Cells' Inflammatory Responses to LPS.

American journal of respiratory cell and molecular biology

Li L,Wei J,Mallampalli RK,Zhao Y,Zhao J

Sun Dec 01 00:00:00 EST 2019

TRIM21 Mitigates Human Lung Microvascular Endothelial Cells' Inflammatory Responses to LPS.

American journal of respiratory cell and molecular biology

Li L,Wei J,Mallampalli RK,Zhao Y,Zhao J

Sun Dec 01 00:00:00 EST 2019

Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease.

Scientific reports

Ahn Y,Hwang JH,Zheng Z,Bang D,Kim DY

Wed Jun 07 00:00:00 EDT 2017

Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease.

Scientific reports

Ahn Y,Hwang JH,Zheng Z,Bang D,Kim DY

Wed Jun 07 00:00:00 EDT 2017

Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease.

Scientific reports

Ahn Y,Hwang JH,Zheng Z,Bang D,Kim DY

Wed Jun 07 00:00:00 EDT 2017

Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease.

Scientific reports

Ahn Y,Hwang JH,Zheng Z,Bang D,Kim DY

Wed Jun 07 00:00:00 EDT 2017

Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.

Antiviral research

Fan W,Zhang D,Qian P,Qian S,Wu M,Chen H,Li X

Tue Mar 01 00:00:00 EST 2016

Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.

Antiviral research

Fan W,Zhang D,Qian P,Qian S,Wu M,Chen H,Li X

Tue Mar 01 00:00:00 EST 2016

Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.

Antiviral research

Fan W,Zhang D,Qian P,Qian S,Wu M,Chen H,Li X

Tue Mar 01 00:00:00 EST 2016

Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.

Antiviral research

Fan W,Zhang D,Qian P,Qian S,Wu M,Chen H,Li X

Tue Mar 01 00:00:00 EST 2016

Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.

The Journal of biological chemistry

Shibata N,Ohoka N,Sugaki Y,Onodera C,Inoue M,Sakuraba Y,Takakura D,Hashii N,Kawasaki N,Gondo Y,Naito M

Fri Nov 20 00:00:00 EST 2015

Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.

The Journal of biological chemistry

Shibata N,Ohoka N,Sugaki Y,Onodera C,Inoue M,Sakuraba Y,Takakura D,Hashii N,Kawasaki N,Gondo Y,Naito M

Fri Nov 20 00:00:00 EST 2015

Bioinformatics

Protein Aliases: 52 kDa ribonucleoprotein autoantigen Ro/SS-A; 52 kDa Ro protein; 52kD Ro/SSA autoantigen; E3 ubiquitin-protein ligase TRIM21; RING finger protein 81; Ro(SS-A); Sicca syndrome antigen A; Sjoegren syndrome type A antigen; Sjogren syndrome antigen A1; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro); SS-A; tripartite motif protein 21; tripartite motif-containing 21; Tripartite motif-containing protein 21

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Gene Aliases: RNF81; Ro/SSA; RO52; SSA; SSA1; TRIM21

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UniProt ID: (Human) P19474

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Entrez Gene ID: (Human) 6737, (Mouse) 20821

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Function(s)

DNA binding RNA binding ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity identical protein binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity ubiquitin-protein ligase

Process(es)

protein polyubiquitination protein monoubiquitination cell cycle positive regulation of autophagy protein ubiquitination protein destabilization negative regulation of NF-kappaB transcription factor activity regulation of type I interferon production negative regulation of viral transcription response to interferon-gamma innate immune response positive regulation of cell cycle positive regulation of viral entry into host cell positive regulation of sequence-specific DNA binding transcription factor activity protein autoubiquitination interferon-gamma-mediated signaling pathway protein trimerization negative regulation of protein deubiquitination negative regulation of viral release from host cell

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TRIM21 Polyclonal Antibody

TRIM21 Antibody (12108-1-AP) in ICC/IF

Product Details

12108-1-AP

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Immunocytochemistry (ICC/IF)

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