Proteintech

TRIP13 Polyclonal Antibody

TRIP13 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TRIP13 Antibody (19602-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse testis tissue slide using 19602-1-AP (TRIP13 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

TRIP13 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

19602-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TRIP13 Fusion Protein Ag6595 (1-301 aa encoded by BC000404)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDEAVGDLK QALPCVAESP TVHVEVHQRG SSTAKKEDIN LSVRKLLNRH NIVFGDYTWT EFDEPFLTRN VQSVSIIDTE LKVKDSQPID LSACTVALHI FQLNEDGPSS ENLEEETENI IAANHWVLPA AEFHGLWDSL VYDVEVKSHL LDYVMTTLLF SDKNVNSNLI TWNRVVLLHG PPGTGKTSLC KALAQKLTIR LSSRYRYGQL IEINSHSLFS KWFSESGKLV TKMFQKIQDL IDDKDALVFV LIDEVESLTA ARNACRAGTE PSDAIRVVNA VLTQIDQIKR HSNVVILTTS NI (1-301 aa encoded by BC000404)

Target Information

Thyroid hormone receptors (TRs) are transcription factors that regulate the expression of specific genes in a hormone-dependent manner. TRIP13 (thyroid hormone receptor interactor 13), also called 16E1BP, is a transcription factor that interacts with the ligand binding domain of the thyroid receptor (TR) as well as a variety of target genes including human papilloma virus type 16 (HPV16) E1. Unlike most TRIP proteins which function only in the presence of hormones, TRIP13 does not require the presence of thyroid hormone to interact with TR. The association of TRIP13 with (HPV16) E1 suggests that TRIP13 may have tumor suppressor gene function. TRIP13 is a 432 amino acid protein with 2 different isoforms produced by alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Antinuclear antibodies in individuals with COVID-19 reflect underlying disease: Identification of new autoantibodies in systemic sclerosis (CDK9) and malignancy (RNF20, RCC1, TRIP13).

Autoimmunity reviews

Bossuyt X,Vulsteke JB,Van Elslande J,Boon L,Wuyts G,Willebrords S,Frans G,Geukens N,Carpentier S,Tejpar S,Wildiers H,Blockmans D,De Langhe E,Vermeersch P,Derua R

Sat Apr 01 00:00:00 EDT 2023

KIFC3 regulates progression of hepatocellular carcinoma via EMT and the AKT/mTOR pathway.

Experimental cell research

Lu S,Liu Y,Tian S,He Y,Dong W

Mon May 01 00:00:00 EDT 2023

TRIP13 overexpression promotes gefitinib resistance in non‑small cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway.

Oncology reports

Xiao Z,Li M,Zhang X,Rong X,Xu H

Mon May 01 00:00:00 EDT 2023

TRIP13 overexpression promotes gefitinib resistance in non‑small cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway.

Oncology reports

Xiao Z,Li M,Zhang X,Rong X,Xu H

Mon May 01 00:00:00 EDT 2023

TRIP13 overexpression promotes gefitinib resistance in non‑small cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway.

Oncology reports

Xiao Z,Li M,Zhang X,Rong X,Xu H

Mon May 01 00:00:00 EDT 2023

Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Rios Garcia M,Meissburger B,Chan J,de Guia RM,Mattijssen F,Roessler S,Birkenfeld AL,Raschzok N,Riols F,Tokarz J,Giroud M,Gil Lozano M,Hartleben G,Nawroth P,Haid M,López M,Herzig S,Berriel Diaz M

Sat Oct 01 00:00:00 EDT 2022

Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Rios Garcia M,Meissburger B,Chan J,de Guia RM,Mattijssen F,Roessler S,Birkenfeld AL,Raschzok N,Riols F,Tokarz J,Giroud M,Gil Lozano M,Hartleben G,Nawroth P,Haid M,López M,Herzig S,Berriel Diaz M

Sat Oct 01 00:00:00 EDT 2022

Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Rios Garcia M,Meissburger B,Chan J,de Guia RM,Mattijssen F,Roessler S,Birkenfeld AL,Raschzok N,Riols F,Tokarz J,Giroud M,Gil Lozano M,Hartleben G,Nawroth P,Haid M,López M,Herzig S,Berriel Diaz M

Sat Oct 01 00:00:00 EDT 2022

Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Rios Garcia M,Meissburger B,Chan J,de Guia RM,Mattijssen F,Roessler S,Birkenfeld AL,Raschzok N,Riols F,Tokarz J,Giroud M,Gil Lozano M,Hartleben G,Nawroth P,Haid M,López M,Herzig S,Berriel Diaz M

Sat Oct 01 00:00:00 EDT 2022

Inducing Synergistic DNA Damage by TRIP13 and PARP1 Inhibitors Provides a Potential Treatment for Hepatocellular Carcinoma.

Journal of Cancer

Xu H,Ma Z,Mo X,Chen X,Xu F,Wu F,Chen H,Zhou G,Xia H,Zhang C

Sat Jul 16 00:00:00 EDT 2022

Evaluation of the TRIP13 level in breast cancer and insights into potential molecular pathways.

Journal of cellular and molecular medicine

Lan J,Huang J,Tao X,Gao Y,Zhang L,Huang W,Luo J,Liu C,Deng Y,Liu L,Liu X

Sun May 01 00:00:00 EDT 2022

Evaluation of the TRIP13 level in breast cancer and insights into potential molecular pathways.

Journal of cellular and molecular medicine

Lan J,Huang J,Tao X,Gao Y,Zhang L,Huang W,Luo J,Liu C,Deng Y,Liu L,Liu X

Sun May 01 00:00:00 EDT 2022

Evaluation of the TRIP13 level in breast cancer and insights into potential molecular pathways.

Journal of cellular and molecular medicine

Lan J,Huang J,Tao X,Gao Y,Zhang L,Huang W,Luo J,Liu C,Deng Y,Liu L,Liu X

Sun May 01 00:00:00 EDT 2022

Evaluation of the TRIP13 level in breast cancer and insights into potential molecular pathways.

Journal of cellular and molecular medicine

Lan J,Huang J,Tao X,Gao Y,Zhang L,Huang W,Luo J,Liu C,Deng Y,Liu L,Liu X

Sun May 01 00:00:00 EDT 2022

TRIP13 promotes the proliferation and invasion of lung cancer cells via the Wnt signaling pathway and epithelial-mesenchymal transition.

Journal of molecular histology

Li ZH,Lei L,Fei LR,Huang WJ,Zheng YW,Yang MQ,Wang Z,Liu CC,Xu HT

Mon Feb 01 00:00:00 EST 2021

SKP1 drives the prophase I to metaphase I transition during male meiosis.

Science advances

Guan Y,Leu NA,Ma J,Chmátal L,Ruthel G,Bloom JC,Lampson MA,Schimenti JC,Luo M,Wang PJ

Sun Mar 01 00:00:00 EST 2020

TRIP13 promotes metastasis of colorectal cancer regardless of p53 and microsatellite instability status.

Molecular oncology

Agarwal S,Behring M,Kim HG,Chandrashekar DS,Chakravarthi BVSK,Gupta N,Bajpai P,Elkholy A,Al Diffalha S,Datta PK,Heslin MJ,Varambally S,Manne U

Tue Dec 01 00:00:00 EST 2020

TRIP13 promotes the cell proliferation, migration and invasion of glioblastoma through the FBXW7/c-MYC axis.

British journal of cancer

Zhang G,Zhu Q,Fu G,Hou J,Hu X,Cao J,Peng W,Wang X,Chen F,Cui H

Sun Dec 01 00:00:00 EST 2019

TRIP13 promotes the cell proliferation, migration and invasion of glioblastoma through the FBXW7/c-MYC axis.

British journal of cancer

Zhang G,Zhu Q,Fu G,Hou J,Hu X,Cao J,Peng W,Wang X,Chen F,Cui H

Sun Dec 01 00:00:00 EST 2019

TRIP13 upregulation is correlated with poor prognosis and tumor progression in esophageal squamous cell carcinoma.

Pathology, research and practice

Di S,Li M,Ma Z,Guo K,Li X,Yan X

Sat Jun 01 00:00:00 EDT 2019

The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility.

PLoS genetics

Gómez-H L,Felipe-Medina N,Condezo YB,Garcia-Valiente R,Ramos I,Suja JA,Barbero JL,Roig I,Sánchez-Martín M,de Rooij DG,Llano E,Pendas AM

Thu Aug 01 00:00:00 EDT 2019

TRIP13 promotes tumor growth and is associated with poor prognosis in colorectal cancer.

Cell death & disease