Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: EVLDLLGNR KHPRSFSTSS TELSQRDDNN DGSGGARAKS KSVSFNLGCK KKTCHGPPLI RTMPRSSGAQ GKSKAESSSK RSFMGPSLKK LGLLFSKFNG HMSEPSSEPM YTISDGIVQQ HCMWQDIRYS QMEKGKAEAC SQSEINLSEV ELGEVQGAAQ SSECPLACSS SLHCASSICS SNSKLLDSSE DVFETWGEAC DLLMHKWGDG QEEQVTTRL (756-973 aa encoded by BC137271)
TRPC5 belongs to the transient receptor family. TRPC5 is one of the seven mammalian TRPC (transient receptor potential channel) proteins. The TRPC5 protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. TRPC5 also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). TRPC5 is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, or G-protein coupled receptors. TRPC5 has also been shown to be calcium-selective, and may also be activated by intracellular calcium store depletion. Diseases associated with TRPC5 include Hypertrophic Pyloric Stenosis and Pyloric Stenosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Capacitative calcium entry channel 2; CCE2; Htrp-5; hTRP5; mtrp5; protein phosphatase 1, regulatory subunit 159; Short transient receptor potential channel 5; transient receptor potential cation channel, subfamily C, member 5; transient receptor potential channel 5; Transient receptor protein 5; TRP-5; Trp-related protein 5; TrpC5; vtransient receptor potential cation channel, subfamily C, member 5
Gene Aliases: CCE2; PPP1R159; TRP-5; TRP5; TRPC5; Trrp5
UniProt ID: (Human) Q9UL62, (Mouse) Q9QX29
Entrez Gene ID: (Human) 7224, (Mouse) 22067
Molecular Function:
ion channel
transporter
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support