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Application
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TRPV2 Antibody (PA1-18346) in ICC/IF
Frontiers in cell and developmental biology 2023 -
FIGURE 3 Protein expression of TRPV2 and TRPV4 in hCMEC/D3. (A) Expression of TRPV2 and TRPV4 determined by Western blot of total crude proteins obtained from two different protein extractions of hCMEC/D3. beta-actin served as a loading control housekeeping protein. (B) Confocal immunofluorescence localization of TRPV2 and TRPV4 in hCMEC/D3. TRPV2 or TRPV4 (green) and nuclei (blue) were stained in hCMEC/D3 ... View More
Product Details
PA1-18346
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues C-K(744) N S A S E E D H L P L Q V L Q S P(761) of rat VRL-1.
Conjugate
Unconjugated
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2287891
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent.
Target Information
VLR-1 is a calcium-permeable, non-selective cation channel with an outward rectification, that seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. VRL-1 does not respond to capsaicin, acid, or moderate heat, but instead is activated by high temperatures, with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium- to large-diameter neurons, making it a candidate receptor for transducing high-threshold heat responses in this class of cells. VRL-1 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat. VRL-1 is one of the six members of the vanilloid-like TRP-channel family which is now known as TRPV family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Osm-9-like TRP channel 2; OTRPC2; RP23-234K24.7; Stretch-activated channel 2B; Transient receptor potential cation channel subfamily V member 2; transient receptor potential cation channel, subfamily V, member 2; TrpV2; Vanilloid receptor-like protein 1; VRL-1
Gene Aliases: Sac2b; TRPV2; VRL; VRL-1; VRL1
UniProt ID: (Human) Q9Y5S1, (Rat) Q9WUD2
Entrez Gene ID: (Human) 51393, (Rat) 29465
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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