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Immunogen sequence: TTHLPDGGVR LLEKSGGLEI IFDVYQADAV ATFRKNNPGK PYARMCISGF DEPVPDLCSL KRLSYQSGDV PLIFALVDHG DISFYSFRDF TLPQDV
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 93%.
This gene encodes a subunit of the tRNA splicing endonuclease complex, which catalyzes the removal of introns from precursor tRNAs. The complex is also implicated in pre-mRNA 3-prime end processing. Mutations in this gene result in pontocerebellar hypoplasia type 2.[provided by RefSeq, Oct 2009].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HsSEN54; SEN54 homolog; tRNA-intron endonuclease Sen54; tRNA-splicing endonuclease subunit Sen54; TSEN54 tRNA splicing endonuclease subunit
Gene Aliases: PCH2A; PCH4; PCH5; SEN54; SEN54L; TSEN54
UniProt ID: (Human) Q7Z6J9
Entrez Gene ID: (Human) 283989
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