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Product Details
CL48867381100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2B7G8
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
TSG101-4A10 recognizes TSG101 protein, the product of a recently identified Tumor Susceptibility Gene whose inactivation in mouse fibroblasts results in cell transformation and the ability of those cells to form tumors in nude mice. The TSG101 gene encodes a 46 kDa protein and contains a proline-rich domain and a leucine-zipper motif within a coiled-coil domain near the carboxyl terminus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ESCRT-I complex subunit TSG101; ESCRTI complex subunit TSG101; TSG 101; Tumor supressor; tumor susceptibility gene 10; tumor susceptibility gene 101; Tumor susceptibility gene 101 protein; tumor susceptibility protein
Gene Aliases: AI255943; CC2; Rw; TSG10; TSG101; VPS23
UniProt ID: (Human) Q99816, (Rat) Q6IRE4, (Mouse) Q61187
Entrez Gene ID: (Human) 7251, (Rat) 292925, (Mouse) 22088
regulation of cell growth
protein monoubiquitination
autophagy
cell cycle arrest
negative regulation of cell proliferation
endosome to lysosome transport
protein transport
endosomal transport
viral life cycle
keratinocyte differentiation
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
regulation of MAP kinase activity
negative regulation of transcription, DNA-templated
viral budding
positive regulation of viral process
cell division
intracellular transport of virus
autophagosome maturation
regulation of viral release from host cell
positive regulation of viral release from host cell
positive regulation of exosomal secretion
regulation of extracellular exosome assembly
regulation of viral budding via host ESCRT complex
positive regulation of viral budding via host ESCRT complex
positive regulation of ubiquitin-dependent endocytosis
cellular protein modification process
cell differentiation
regulation of growth
regulation of nucleic acid-templated transcription
transport
cell cycle
viral process
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