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TSHZ3 Antibody (PA5-116843) in WB
Western blot analysis of TSHZ3 in extracts of various cell lines. Samples were incubated with TSHZ3 Polyclonal antibody (Product # PA5-116843) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-116843
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 791-890 of human TSHZ3 (NP_0659072)
Conjugate
Form
Liquid
Concentration
1.09 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2901474
Product Specific Information
Positive Samples: U-87MG, HepG2
Immunogen sequence: DLTKGKSDKG CSLGSVLLSP TSTAPATSSS TVTTAKTSAV VSFMSNSPLR ENALSDISDM LKNLTESHTS KSSTPSSISE KSDIDGATLE EAEESTPAQK
Target Information
The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. In mice, the known three TSHZ proteins are expressed in distinct patterns in the developing and adult brain, suggesting that they play a role in the establishment of regional identity and specification of cell types within the brain. Both TSHZ3 and TSHZ1 have been found to interact with FE65, an adapter protein that binds to the amyloid protein precursor (APP) in neurons. Together with SET, a component of the inhibitor of acetyl transferase, and histone deacetylases, these proteins formed a gene-silencing complex whose target includes caspase-4. Recent experiments have also suggested this family of proteins may be involved in carcinogenesis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: teashirt 3; Teashirt homolog 3; Zinc finger protein 537
Gene Aliases: A630038G13Rik; KIAA1474; mKIAA1474; teashirt3; TSH3; TSHZ3; Zfp537; ZNF537
UniProt ID: (Human) Q63HK5, (Mouse) Q8CGV9
Entrez Gene ID: (Human) 57616, (Mouse) 243931
ureteric bud development
in utero embryonic development
regulation of respiratory gaseous exchange by neurological system process
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
regulation of gene expression
lung development
negative regulation of transcription, DNA-templated
smooth muscle tissue development
musculoskeletal movement
sensory perception of touch
positive regulation of smooth muscle cell differentiation
kidney morphogenesis
ureteric peristalsis
ureter smooth muscle cell differentiation
kidney smooth muscle cell differentiation
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