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Peptide sequence: MASVVVKTIW QSKEIHEAGD TPTGVESCSQ LVPEAPRRVT SRAKGIPKKK
Sequence homology: Cow: 86%; Dog: 86%; Human: 100%; Mouse: 86%; Pig: 86%; Rabbit: 79%; Rat: 86%
A novel putative serine/threonine kinase substrate gene (TSKS, for testis-specific kinase substrate) is likely the human homolog of the mouse testis-specific serine kinase substrate gene. TSKS exhibits high levels of expression exclusively in human testicular tissue. The expression of TSKS is downregulated in cancerous testicular tissue, in comparison to adjacent normal tissue. These observations suggest a role of TSKS in testicular physiology, most probably in the process of spermatogenesis or spermiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: protein phosphatase 1, regulatory subunit 161; STK22 substrate 1; testis specific serine/threonine kinase substrate; Testis-specific kinase substrate; Testis-specific serine kinase substrate
Gene Aliases: PPP1R161; STK22S1; TSKS; TSKS1; TSSKS
UniProt ID: (Human) Q9UJT2
Entrez Gene ID: (Human) 60385
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