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Product Details
BS-6026R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CADM1/TSLC1, amino acids 65-160.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Mediates homophilic cell-cell adhesion in a Ca (2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca (2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CADM1; Cell adhesion molecule 1; cell adhesion molecule 1 transcript variant 8abc; IgSF4; Immunoglobulin superfamily member 4; immunoglobulin superfamily member 4A; immunoglobulin superfamily, member 4; immunoglobulin superfamily, member 4A; immunoglobulin superfamily, member 4D variant 1; immunoglobulin superfamily, member 4D variant 2; immunosuperfamily protein Bl2; NECL-2; nectin-like 2; Nectin-like protein 2; secretory isoform of TSLC1; SgIgSF; Spermatogenic immunoglobulin superfamily; Synaptic cell adhesion molecule; SynCAM; truncated CADM1 protein; TSLC-1; TSLC1/Nectin-like 2/IGSF4; Tumor suppressor in lung cancer 1; Tumor suppressor in lung cancer 1 homolog
Gene Aliases: 2900073G06Rik; 3100001I08Rik; AI987920; BL2; CADM1; IGSF4; IGSF4A; Necl-2; NECL2; RA175; RA175A; RA175B; RA175C; RA175N; SgIGSF; ST17; sTSLC-1; SYNCAM; SynCam1; TSLC1
UniProt ID: (Human) Q9BY67, (Mouse) Q8R5M8, (Rat) Q6AYP5
Entrez Gene ID: (Human) 23705, (Mouse) 54725, (Rat) 363058
liver development
immune system process
apoptotic process
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
multicellular organism development
spermatogenesis
synapse assembly
cell recognition
unidimensional cell growth
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
cell differentiation
susceptibility to natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of cytokine secretion
detection of stimulus
bone development
T cell mediated cytotoxicity
adherens junction organization
activated T cell proliferation
brain development
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