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Predicted to react with Mouse and Rat samples.
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cancer/testis antigen 72; CT72; serine/threonine protein kinase SSTK; Serine/threonine-protein kinase SSTK; Small serine/threonine kinase; testis secretory sperm-binding protein Li 205a; testis-specific kinase 6; testis-specific serine kinase 6; Testis-specific serine/threonine-protein kinase 6; TSK-6; TSSK-6; TSSK6
Gene Aliases: CT72; FKSG82; RGD1559764; SSTK; TSSK4; TSSK6
UniProt ID: (Human) Q9BXA6, (Mouse) Q925K9
Entrez Gene ID: (Human) 83983, (Mouse) 83984, (Rat) 290670
Molecular Function:
non-receptor serine/threonine protein kinase
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