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            Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

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            • Primary Antibodies ›
            • TdT Antibodies
            Now available in recombinant format (Product # 740077M) in both full and sample sizes.

            Invitrogen

            TdT Monoclonal Antibody (7UNA8U6), eBioscience™

            Advanced Verification
            1 Published Figure
            1 Reference
            View all (39) TdT antibodies
            Datasheet
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            Catalog # 14-9739-82
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            Cite TdT Monoclonal Antibody (7UNA8U6), eBioscience™

            • Antibody Testing Data (2)
            • Published Figures (1)
            • Advanced Verification (1)
            Application
            TdT Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Group 53 Created with Sketch.

            FIGURE: 1 / 4

            TdT Antibody (14-9739-82) in IHC (P)

            Immunohistochemistry of formalin-fixed paraffin embedded human thymus using 10 µg/mL of Anti-TdT Purified followed by Anti-Mouse Biotin, Streptavidin-HRP, and DAB visualization.Nuclei are counterstained with hematoxylin.
            View Product

            TdT Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            TdT Antibody in Western Blot (WB)
            TdT Antibody in Western Blot (WB)
            TdT Antibody

            Product Details

            14-9739-82

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            5 µg/mL
            View 1 publication 1 publication

            Immunohistochemistry (Paraffin) (IHC (P))

            10 µg/mL
            -
            Product Specifications

            Species Reactivity

            Human, Mouse, Rat

            Host/Isotype

            Mouse / IgG1, kappa

            Class

            Monoclonal

            Type

            Antibody

            Clone

            7UNA8U6

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.5 mg/mL

            Purification

            Affinity chromatography

            Storage buffer

            PBS, pH 7.2

            Contains

            0.09% sodium azide

            Storage conditions

            4°C

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2572966

            Product Specific Information

            Description: The monoclonal antibody 7UNA8U6 reacts with human, mouse, and rat TdT. TdT, or terminal-deoxynucleotidyl transferase, is a 60 kDa polymerase responsible for the template-independent addition of N-nucleotides at gene segment junctions of developing lymphocytes. Expression is found in the nucleus of immature lymphocytes but not in mature lymphocytes or non-lymphoid cells. TdT plays a critical role during TCR and Ig gene rearrangement and functions to increase the diversity of the lymphocyte repertoire through the addition of N-nucleotides onto the ends of newly formed P-nucleotides. After positive selection, expression of TdT becomes decreased or absent. Expression of TdT has been shown to be present in lymphoma or lymphoblastic leukemia cells.

            Applications Reported: This 7UNA8U6 antibody has been reported for use in western blotting and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.

            Applications Tested: This 7UNA8U6 antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded human and mouse tissue using low pH antigen retrieval and can be used at less than or equal to 10 µg/mL. This 7UNA8U6 antibody has also been tested by western blot analysis of reduced cell lysate prepared from mouse and rat cells and can be used at less than or equal to 5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

            Purity: Greater than 90%, as determined by SDS-PAGE.

            Aggregation: Less than 10%, as determined by HPLC.

            Filtration: 0.2 µm post-manufacturing filtered.

            Target Information

            Terminal Deoxynucleotidyl Transferase (TdT) is a DNA polymerase located in the cell nucleus which catalyses the polymerization of deoxynucleotides at the 3' hydroxyl ends of oligo or polydeoxynucleotide initiators and functions without a template. TdT is considered to be a highly specific marker for the diagnosis and classification of acute lymphoblastic lymphoma/leuksemias. The determination of TdT expression is most valuable when it is different to differentiate histologically between lymphoblastic lymphoma and Burkitt's lymphoma.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            Related Products for

            Bioinformatics

            Protein Aliases: Deoxynucleotidyltransferase terminal; deoxynucleotidyltransferase, terminal; DNA nucleotidylexotransferase; Nucleosidetriphosphate DNA Deoxynucleotidylexotransferase; nucleosidetriphosphate:DNA deoxynucleotidylexotransferase; TDT; Terminal addition enzyme; terminal deoxynucleotidyl transferase; Terminal deoxynucleotidyltransferase; terminal deoxyribonucleotidyltransferase; Terminal transferase

            View more View less

            Gene Aliases: DNTT; TDT

            View more View less

            UniProt ID: (Human) P04053, (Mouse) P09838

            View more View less

            Entrez Gene ID: (Human) 1791, (Mouse) 21673, (Rat) 294051

            View more View less

            Function(s)

            DNA binding DNA-directed DNA polymerase activity DNA nucleotidylexotransferase activity protein binding metal ion binding transferase activity nucleotidyltransferase activity DNA polymerase activity DNA-directed DNA polymerase

            Process(es)

            DNA metabolic process DNA modification DNA biosynthetic process response to ATP
            It has to be done as per old AB suggested Products section.
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            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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