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Invitrogen
Tensin 3 Polyclonal Antibody
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Application
FIGURE: 1 / 5
Tensin 3 Antibody (PA5-63112) in ICC/IF
Immunofluorecent analysis of Tensin 3 in human cell line U-251 MG using Tensin 3 Polyclonal Antibody (Product # PA5-63112). Staining shows localization to focal adhesion sites.
Product Details
PA5-63112
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Tensin 3. Recombinant protein control fragment (Product #RP-103213).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.30 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2648381
Product Specific Information
Immunogen sequence: HLGPFTCHKS SQNSLLSDGF GSNVGEDPQG TLVPDLGLGM DGPYERERTF GSREPKQPQP LLRKPSVSAQ MQAYGQSSYS TQTWVRQQQM VVAHQYSFAP DGEAR
Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 75%.
Target Information
The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring actin filaments at the focal adhesion via F-actin binding and capping activities. Tns proteins also contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting a role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns3, also known as TEM6 or TENS1, localizes to the focal adhesions of the plasma membrane. It is predominantly expressed in thyroid and placenta but can also be found in heart, liver, brain, prostate, pancreas, kidney, lung, skeletal muscle and white blood cells. Tns3 is essential for proper growth and development, as suggested by growth retardation and death in a number of Tns3-/- mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: TENS3; Tensin-3; tensin-like SH2 domain containing 1; tensin-like SH2 domain-containing 1; Tensin-like SH2 domain-containing protein 1; thyroid specific PTB domain protein; Tumor endothelial marker 6
Gene Aliases: TEM6; TENS1; TNS3; TPP
UniProt ID: (Human) Q68CZ2
Entrez Gene ID: (Human) 64759
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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