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Invitrogen

Torsin 1A Polyclonal Antibody

View all (9) Torsin 1A antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (2)

Application

Torsin 1A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 2

Torsin 1A Antibody (PA5-102569) in IHC (P)

Immunohistochemistry analysis of Torsin 1A in human prostate cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Torsin 1A polyclonal antibody (Product # PA5-102569) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.

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Product Details

PA5-102569

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TOR1A(Accession O14656), corresponding to amino acid residues G225-K275.

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2851971

Product Specific Information

Antibody detects endogenous levels of total TOR1A.

Target Information

The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dystonia 1; Dystonia 1 protein; Dystonia 1 torsion; dystonia 1, torsion (autosomal dominant; dystonia 1, torsion (autosomal dominant; torsin A); Torsin 1A; torsin A; Torsin ATPase 1; Torsin ATPase-1A; Torsin family 1 member A; torsin family 1, member A (torsin A); Torsin-1A

Gene Aliases: DQ2; DYT1; TA; TOR1A; TORA; torsinA

UniProt ID: (Human) O14656, (Rat) Q68G38, (Mouse) Q9ER39

Entrez Gene ID: (Human) 1861, (Rat) 266606, (Mouse) 30931

Function(s)

protein binding ATP binding cytoskeletal protein binding ATPase activity kinesin binding unfolded protein binding misfolded protein binding nucleotide binding hydrolase activity chaperone

Process(es)

protein deneddylation response to oxidative stress organelle organization nuclear envelope organization cell adhesion neuron projection development protein localization to nucleus wound healing, spreading of cells intermediate filament cytoskeleton organization synaptic vesicle transport chaperone mediated protein folding requiring cofactor protein homooligomerization regulation of dopamine uptake involved in synaptic transmission chaperone-mediated protein folding ER-associated misfolded protein catabolic process nuclear membrane organization chaperone-mediated protein transport positive regulation of synaptic vesicle endocytosis regulation of protein localization to cell surface

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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