Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
FIGURE: 1 / 1
Specificity: This antibody binds to the extracellular domain of TrkA. It was shown not to cross react with TrkB. Moreover MNAC13 is specific to TrkA with negligible reactivity to TrkB and TrkC.
NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp781I14186; EC 2.7.10.1; gp140trk; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; p140-TrkA; Trk-A; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A
Gene Aliases: MTC; NTRK1; p140-TrkA; TRK; Trk-A; TRK1; TRKA
UniProt ID: (Human) P04629
Entrez Gene ID: (Human) 4914
Molecular Function:
transmembrane signal receptor
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