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            • Primary Antibodies ›
            • TrkA Antibodies

            Alomone Labs, LTD

            TrkA (extracellular) Polyclonal Antibody, FITC

            View all (50) TrkA antibodies

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            Datasheet
            Protocols
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            Catalog # ANT-018-F-50UL
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            Price (USD)
            900.00
            50 µL
             
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            Cite TrkA (extracellular) Polyclonal Antibody, FITC

            • Antibody Testing Data (2)
            Application
            TrkA (extracellular) Antibody in Flow Cytometry (Flow)
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            TrkA (extracellular) Antibody (ANT-018-F-50UL) in Flow

            Cell surface detection of TrkA in live intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + Rabbit IgG Isotype Control-FITC. (green) Cells + Anti-TrkA (extracellular)-FITC Antibody (#ANT-018-F), (2.5 µg).
            View Product

            TrkA (extracellular) Antibody in Flow Cytometry (Flow)
            TrkA (extracellular) Antibody in Flow Cytometry (Flow)

            Product Details

            ANT-018-F-50UL

            Applications
            Tested Dilution
            Publications

            Flow Cytometry (Flow)

            5 µg
            -
            Product Specifications

            Species Reactivity

            Human, Mouse, Rat

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            (C)ETMRHG(S)LRLNQPTH, corresponding to amino acid residues 342-356 of rat TrkA, Extracellular, N-terminus
            View immunogen

            Conjugate

            FITC

            Excitation/Emission Max

            498/517 nm View spectra spectra

            Form

            Lyophilized

            Concentration

            1 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            PBS, pH 7.4, with 1% BSA

            Contains

            0.05% sodium azide

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles, store in dark

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Product Specific Information

            Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

            Target Information

            NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            How to build a flow cytometry experiment with Invitrogen Flow Cytometry Panel Builder
            The Invitrogen Flow Cytometry Panel Builder webtool helps you chose antibody clones, fluorophores, fluorescent proteins, and reagents to design your experiment.
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            Cite this product

            Bioinformatics

            Protein Aliases: DKFZp781I14186; EC 2.7.10.1; gp140trk; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; p140-TrkA; Slow nerve growth factor receptor; trk; Trk-A; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A

            View more View less

            Gene Aliases: C80751; MTC; NTRK1; p140-TrkA; Tkr; TRK; Trk-A; TRK1; TRKA

            View more View less

            UniProt ID: (Human) P04629, (Mouse) Q3UFB7, (Rat) P35739

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            Entrez Gene ID: (Human) 4914, (Mouse) 18211, (Rat) 59109

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            Function(s)

            transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase binding protein homodimerization activity neurotrophin binding nerve growth factor binding nucleotide binding protein kinase activity protein tyrosine kinase activity neurotrophin receptor activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ephrin receptor binding transmembrane signal receptor

            Process(es)

            activation of MAPKK activity positive regulation of protein phosphorylation protein phosphorylation microtubule-based movement axon guidance aging learning or memory circadian rhythm negative regulation of cell proliferation response to radiation programmed cell death involved in cell development positive regulation of neuron projection development response to activity peptidyl-tyrosine phosphorylation olfactory nerve development B cell differentiation response to nutrient levels nerve growth factor signaling pathway mechanoreceptor differentiation response to drug positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of GTPase activity response to ethanol positive regulation of Ras protein signal transduction protein autophosphorylation neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway phosphatidylinositol-mediated signaling sympathetic nervous system development response to axon injury detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity response to hydrostatic pressure response to electrical stimulus positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic Sertoli cell development axonogenesis involved in innervation behavioral response to formalin induced pain positive regulation of ERK1 and ERK2 cascade cellular response to nicotine cellular response to nerve growth factor stimulus transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development phosphorylation sensory perception of pain cell differentiation response to nicotine positive regulation of angiogenesis innervation cellular response to growth factor stimulus negative regulation of neuron death
            It has to be done as per old AB suggested Products section.
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