Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
Positive Samples: Mouse spinal cord, Mouse brain, Rat brain
Immunogen sequence: INFTRNKLTS LSRRHFRHLD LSDLILTGNP FTCSCDIMWL KTLQETKSSP DTQDLYCLNE SSKNMPLANL QIPNCGLPSA RLAAPNLTVE EGKSVTLSCS VGGDPLPTLY WDVGNLVSKH MNETSHTQGS LRITNISSDD SGKQISCVAE NLVGEDQDSV NLTVHFAPTI TFLESPTSDH HWCIPFTVRG NPKPALQWFY NGAILNESKY ICTKIHVTNH TEYHGCLQLD NPTHMNNGDY TLMAKNEYGK DERQISAHFM GRPGVDYETN PNYPEVLYED WTTPTDIGDT TNKSNEIPST DVADQSNREH L
NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses. TrkB is involved in the development and maintenance of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AI848316; BDNF/NT-3 growth factors receptor; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145-TrkB/GP95-TrkB; GP145TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; neural receptor protein-tyrosine kinase (trkB); Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine receptor kinase type 2; NTRK 2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; Trk B; Trk-B; TrkB tyrosine kinase
Gene Aliases: GP145-TrkB/GP95-TrkB; Ntrk2; RATTRKB1; Tkrb; trk-B; Trkb; TRKB1
UniProt ID: (Mouse) P15209, (Rat) Q63604
Entrez Gene ID: (Mouse) 18212, (Rat) 25054
Molecular Function:
transmembrane signal receptor
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