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Invitrogen
TrkC Recombinant Rabbit Monoclonal Antibody (7H3L20)
Advanced Verification
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
TrkC Antibody (701985) in ICC/IF
For immunofluorescence analysis, retinoic acid (10 uM, 72 hours) treated SH-SY5Y cells were fixed and permeabilized for detection of endogenous TrkC using Anti-TrkC Recombinant Rabbit Monoclonal Antibody (Product # 701985, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of TrkC protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Anti... View More
Product Details
701985
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
7H3L20
Immunogen
Protein corresponding to Human NTRK3 (aa 200-429)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2633043
Product Specific Information
This antibody is predicted to react with Monkey, Mouse and Rat.^M
^M
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin-3; NT-3 growth factor receptor; Trk-C; TrkC tyrosine kinase; tyrosine kinase receptor C
Gene Aliases: AW125844; gp145(trkC); GP145-TrkC; NTRK3; Ntrk3_tv3; TRKC
UniProt ID: (Human) Q16288, (Mouse) Q6VNS1
Entrez Gene ID: (Human) 4916, (Mouse) 18213
p53 binding
GPI-linked ephrin receptor activity
neurotrophin receptor activity
protein binding
ATP binding
neurotrophin binding
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
ephrin receptor binding
transmembrane signal receptor
activation of MAPK activity
neuron migration
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
heart development
circadian rhythm
positive regulation of cell proliferation
positive regulation of gene expression
peptidyl-tyrosine phosphorylation
modulation by virus of host transcription
positive regulation of cell migration
activation of protein kinase B activity
positive regulation of peptidyl-serine phosphorylation
neurotrophin signaling pathway
mechanoreceptor differentiation
positive regulation of apoptotic process
response to ethanol
protein autophosphorylation
ephrin receptor signaling pathway
neuron fate specification
response to axon injury
positive regulation of axon extension involved in regeneration
negative regulation of astrocyte differentiation
positive regulation of positive chemotaxis
response to corticosterone
positive regulation of synapse assembly
negative regulation of cell death
lens fiber cell differentiation
cellular response to retinoic acid
cochlea development
activation of GTPase activity
positive regulation of actin cytoskeleton reorganization
protein phosphorylation
multicellular organism development
nervous system development
phosphorylation
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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