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            • Primary Antibodies ›
            • TPM1 Antibodies

            NeoBiotechnologies

            Tropomyosin, alpha-1 chain (striated muscle) Monoclonal Antibody (TPM1/4510)

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            Catalog # 7168-MSM1-P1
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            Cite Tropomyosin, alpha-1 chain (striated muscle) Monoclonal Antibody (TPM1/4510)

            • Antibody Testing Data (2)
            Application
            Tropomyosin, alpha-1 chain (striated muscle) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Group 53 Created with Sketch.

            FIGURE: 1 / 2

            Tropomyosin, alpha-1 chain (striated muscle) Antibody (7168-MSM1-P1) in IHC (P)

            Formalin-fixed, paraffin-embedded human skeletal muscle stained with Tropomyosin Mouse Monoclonal Antibody (TPM1/4510). HIER: Tris/EDTA, pH9.0, 45 min. 2°C: HRP-polymer, 30 min. DAB, 5 min.
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            Tropomyosin, alpha-1 chain (striated muscle) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Tropomyosin, alpha-1 chain (striated muscle) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

            Product Details

            7168-MSM1-P1

            Applications
            Tested Dilution
            Publications

            Immunohistochemistry (Paraffin) (IHC (P))

            1-2 µg/mL
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Mouse / IgG1

            Class

            Monoclonal

            Type

            Antibody

            Clone

            TPM1/4510

            Immunogen

            Recombinant full-length TPM1 protein
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            200 µg/mL

            Purification

            Protein A/G

            Storage buffer

            PBS with 0.05% BSA

            Contains

            0.05% sodium azide

            Storage conditions

            4°C

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Product Specific Information

            Positive Control:Human heart.

            Cellular Location: Cytoplasm. Cytoskeleton.

            Target Information

            Tropomyosin is a dimeric coiled-coil protein that binds along the length of actin filaments. It is associated with the thin filaments of muscle cells and the microfilaments of nonmuscle cells. Chicken embryo fibroblasts (CEF) contain five isoforms of tropomyosin (a, b, 1, 2, and 3), identified as such by their different apparent molecular masses after separation by SDS-PAGE, but similar biochemical properties, such as resistance to heat and organic solvents, the ability to bind to F-actin filaments, and the lack of proline and tryptophan.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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            Cite this product

            Bioinformatics

            Protein Aliases: Alpha-tropomyosin; cardiomyopathy, hypertrophic 3; epididymis secretory protein Li 265; sarcomeric tropomyosin kappa; TPM1-alpha; tropomyosin; Tropomyosin alpha-1 chain; Tropomyosin-1

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            Gene Aliases: C15orf13; CMD1Y; CMH3; HEL-S-265; HTM-alpha; LVNC9; TMSA; TPM1

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            UniProt ID: (Human) P09493

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            Entrez Gene ID: (Human) 7168

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            Function(s)

            actin binding structural constituent of cytoskeleton protein binding cytoskeletal protein binding structural constituent of muscle actin binding motor protein

            Process(es)

            in utero embryonic development positive regulation of heart rate by epinephrine movement of cell or subcellular component muscle contraction regulation of muscle contraction cytoskeleton organization regulation of heart contraction regulation of cell shape muscle filament sliding negative regulation of cell migration ruffle organization positive regulation of ATPase activity cellular response to reactive oxygen species wound healing sarcomere organization positive regulation of cell adhesion positive regulation of stress fiber assembly ventricular cardiac muscle tissue morphogenesis cardiac muscle contraction negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration
            It has to be done as per old AB suggested Products section.
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