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FIGURE: 1 / 2
Positive test controls include: Rat brain. The target is usually found in the following locations: Melanosome membrane, Single-pass type I membrane protein.
Immunogen sequence: PWSGDRSPCG QLSGRGSCQN ILLSNAPLGP QFPFTGVDDR ESWPSVFYNR TCQCSGNFMG FNCGNCKFGF WGPNCTERRL LVRRNIFDLS APEKDKFFAY LTLAKHTISS DYVIPIGTYG QMKNGSTPMF NDINIYDLFV WMHYYVSMDA LLGGSEIWRD IDFAHEAPAF LPWHRLFLLR WEQEIQKLTG DENFTIPYWD WRDAEKCDIC TDEYMGGQHP TNPNLLSPAS FFSSWQIVCS RLEEYNSHQS LCNGTPEGPL RRNPGNHDKS RTPRLPSSAD VEFCLSLTQY ESGSMDKAAN FSFRNTLEGF ASPLTGIADA S
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Albino locus protein; LB24-AB; Monophenol monooxygenase; oculocutaneous albinism IA; SK29-AB; Tumor rejection antigen AB; Tyrosinase
Gene Aliases: albino; ATN; C; CMM8; OCA1; OCA1A; OCAIA; SHEP3; skc35; TYR
UniProt ID: (Human) P14679, (Mouse) P11344
Entrez Gene ID: (Human) 7299, (Mouse) 22173, (Rat) 308800
Molecular Function:
oxygenase
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