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Proteintech

UCHL3 Polyclonal Antibody

14 References

View all (24) UCHL3 antibodies

Datasheet

Protocols

Questions & Answers

Tech Support

Catalog # 12384-1-AP

Price (EUR)

437,00

150 µL

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Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (5)

Application

UCHL3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

UCHL3 Antibody (12384-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas cancer using 12384-1-AP (UCHL3 antibody) at dilution of 1:50 (under 10x lens).

UCHL3 Antibody in Immunoprecipitation (IP)

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Product Details

12384-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

UCHL3 Fusion Protein Ag3053 (1-230 aa encoded by BC018125)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEGQRWLPL EANPEVTNQF LKQLGLHPNW QFVDVYGMDP ELLSMVPRPV CAVLLLFPIT EKYEVFRTEE EEKIKSQGQD VTSSVYFMKQ TISNACGTIG LIHAIANNKD KMHFESGSTL KKFLEESVSM SPEERARYLE NYDAIRVTHE TSAHEGQTEA PSIDEKVDLH FIALVHVDGH LYELDGRKPF PINHGETSDE TLLEDAIEVC KKFMERDPDE LRFNAIALSA A (1-230 aa encoded by BC018125)

Target Information

Regulatory associated protein of mTOR (RAPTOR) is a binding partner of target of rapamycin (TOR). It binds to 4EBP1 and p70alpha. The binding of raptor to mTOR is essential for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro. It enhances the mTOR kinase activity toward p70alpha. It is also an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The deubiquitinating enzyme UCHL3 promotes anaplastic thyroid cancer progression and metastasis through Hippo signaling pathway.

Cell death and differentiation

Tang J,Yang Q,Mao C,Xiao D,Liu S,Xiao L,Zhou L,Wu G,Tao Y

Mon May 01 00:00:00 UTC 2023

The deubiquitinating enzyme UCHL3 promotes anaplastic thyroid cancer progression and metastasis through Hippo signaling pathway.

Cell death and differentiation

Tang J,Yang Q,Mao C,Xiao D,Liu S,Xiao L,Zhou L,Wu G,Tao Y

Mon May 01 00:00:00 UTC 2023

The deubiquitinating enzyme UCHL3 promotes anaplastic thyroid cancer progression and metastasis through Hippo signaling pathway.

Cell death and differentiation

Tang J,Yang Q,Mao C,Xiao D,Liu S,Xiao L,Zhou L,Wu G,Tao Y

Mon May 01 00:00:00 UTC 2023

Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer.

Nature communications

Zhang W,Wang M,Song Z,Fu Q,Chen J,Zhang W,Gao S,Sun X,Yang G,Zhang Q,Yang J,Tang H,Wang H,Kou X,Wang H,Mao Z,Xu X,Gao S,Jiang Y

Mon Apr 03 00:00:00 UTC 2023

UCHL3 promotes hepatocellular carcinoma cell migration by de-ubiquitinating and stabilizing Vimentin.

Frontiers in oncology

Ma Q,Lu Q,Lei X,Zhao J,Sun W,Wang J,Zhu Q,Huang D

Tue Mar 28 00:00:00 UTC 2023

UCHL3 promotes hepatocellular carcinoma cell migration by de-ubiquitinating and stabilizing Vimentin.

Frontiers in oncology

Ma Q,Lu Q,Lei X,Zhao J,Sun W,Wang J,Zhu Q,Huang D

Tue Mar 28 00:00:00 UTC 2023

UCHL3 promotes hepatocellular carcinoma cell migration by de-ubiquitinating and stabilizing Vimentin.

Frontiers in oncology

Ma Q,Lu Q,Lei X,Zhao J,Sun W,Wang J,Zhu Q,Huang D

Tue Mar 28 00:00:00 UTC 2023

Structural basis for specific inhibition of the deubiquitinase UCHL1.

Nature communications

Grethe C,Schmidt M,Kipka GM,O'Dea R,Gallant K,Janning P,Gersch M

Mon Oct 10 00:00:00 UTC 2022

Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).

Scientific reports

Lei Q,Yi T,Li H,Yan Z,Lv Z,Li G,Wang Y

Tue Jun 30 00:00:00 UTC 2020

UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1 stabilization.

American journal of cancer research

Song Z,Li J,Zhang L,Deng J,Fang Z,Xiang X,Xiong J

Wed Sep 30 00:00:00 UTC 2020

UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1 stabilization.

American journal of cancer research

Song Z,Li J,Zhang L,Deng J,Fang Z,Xiang X,Xiong J

Wed Sep 30 00:00:00 UTC 2020

The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.

Scientific reports

Nishi R,Wijnhoven PWG,Kimura Y,Matsui M,Konietzny R,Wu Q,Nakamura K,Blundell TL,Kessler BM

Mon Dec 17 00:00:00 UTC 2018

The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.

Scientific reports

Nishi R,Wijnhoven PWG,Kimura Y,Matsui M,Konietzny R,Wu Q,Nakamura K,Blundell TL,Kessler BM

Mon Dec 17 00:00:00 UTC 2018

An Interaction Landscape of Ubiquitin Signaling.

Molecular cell

Zhang X,Smits AH,van Tilburg GB,Jansen PW,Makowski MM,Ovaa H,Vermeulen M

Thu Mar 02 00:00:00 UTC 2017

An Interaction Landscape of Ubiquitin Signaling.

Molecular cell

Zhang X,Smits AH,van Tilburg GB,Jansen PW,Makowski MM,Ovaa H,Vermeulen M

Thu Mar 02 00:00:00 UTC 2017

A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.

Genes & development

Luo K,Li L,Li Y,Wu C,Yin Y,Chen Y,Deng M,Nowsheen S,Yuan J,Lou Z

Thu Dec 01 00:00:00 UTC 2016

A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.

Genes & development

Luo K,Li L,Li Y,Wu C,Yin Y,Chen Y,Deng M,Nowsheen S,Yuan J,Lou Z

Thu Dec 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: testicular tissue protein Li 221; ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); Ubiquitin carboxyl-terminal hydrolase isozyme L3; Ubiquitin thioesterase L3; ubiquitin thiolesterase; UCH-L3

Gene Aliases: RGD1561196; UCH-L3; UCHL3

UniProt ID: (Human) P15374, (Mouse) Q9JKB1, (Rat) Q91Y78

Entrez Gene ID: (Human) 7347, (Mouse) 50933, (Rat) 498560

Function(s)

thiol-dependent ubiquitin-specific protease activity protein binding peptidase activity ubiquitin binding cysteine-type peptidase activity hydrolase activity cysteine protease

Process(es)

ubiquitin-dependent protein catabolic process protein deubiquitination protein catabolic process proteolysis adult walking behavior cellular response to insulin stimulus eating behavior positive regulation of fat cell differentiation retina development in camera-type eye

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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UCHL3 Polyclonal Antibody

UCHL3 Antibody (12384-1-AP) in IHC (P)

Product Details

12384-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Function(s)

Process(es)

Performance Guarantee

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