Proteintech

UCP2 Polyclonal Antibody

UCP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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UCP2 Antibody (11081-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using (Product # 11081-1-AP) (UCP2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

UCP2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11081-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 44 publications 44 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 8 publications 8 publications

Immunoprecipitation (IP)

1:500

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

UCP2 Fusion Protein Ag1551 (1-309 aa encoded by BC011737)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody detect a band around 28-33 kDa corresponding to UCP2 protein in mouse liver, skeletal muscle and pancreas. Some upper and lower bands also were observed due to the dimer formation and degradation of the UCP2 protein. This antibody was raised against the full-length UCP2 protein and may cross-react with UCP3. It is notable that UCP2 is known to have a very short half-life less than 1 hour. It is strongly recommended that fresh-made lysate be used for western blot assays.

Immunogen sequence: MVGFKATDV PPTATVKFLG AGTAACIADL ITFPLDTAKV RLQIQGESQG PVRATASAQY RGVMGTILTM VRTEGPRSLY NGLVAGLQRQ MSFASVRIGL YDSVKQFYTK GSEHASIGSR LLAGSTTGAL AVAVAQPTDV VKVRFQAQAR AGGGRRYQST VNAYKTIARE EGFRGLWKGT SPNVARNAIV NCAELVTYDL IKDALLKANL MTDDLPCHFT SAFGAGFCTT VIASPVDVVK TRYMNSALGQ YSSAGHCALT MLQKEGPRAF YKGFMPSFLR LGSWNVVMFV TYEQLKRALM AACTSREAPF (1-309 aa encoded by BC011737)

Target Information

UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non shivering thermogenesis, obesity and diabetes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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mRNA m⁶A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.

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Chen GD,Zhang JL,Chen YT,Zhang JX,Wang T,Zeng QY

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Experimental and therapeutic medicine

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Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice.

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Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.

Scientific reports

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Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury.

Science translational medicine

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Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury.

Science translational medicine

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Thu Jun 01 00:00:00 EDT 2017

Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.

Food & function

He K,Li X,Xiao Y,Yong Y,Zhang Z,Li S,Zhou T,Yang D,Gao P,Xin X

Wed Aug 10 00:00:00 EDT 2016

Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.

Food & function

He K,Li X,Xiao Y,Yong Y,Zhang Z,Li S,Zhou T,Yang D,Gao P,Xin X

Wed Aug 10 00:00:00 EDT 2016

Mechanism of uncoupling protein 2‑mediated myocardial injury in hypothermic preserved rat hearts.

Molecular medicine reports

Chen GG,Yan JB,Wang XM,Zheng MZ,Jiang JP,Zhou XM,Cai B,Shen YL

Mon Aug 01 00:00:00 EDT 2016

Mechanism of uncoupling protein 2‑mediated myocardial injury in hypothermic preserved rat hearts.

Molecular medicine reports

Chen GG,Yan JB,Wang XM,Zheng MZ,Jiang JP,Zhou XM,Cai B,Shen YL

Mon Aug 01 00:00:00 EDT 2016

Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.

Biochimica et biophysica acta

He K,Hu Y,Ma H,Zou Z,Xiao Y,Yang Y,Feng M,Li X,Ye X

Thu Sep 01 00:00:00 EDT 2016

Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.

Biochimica et biophysica acta

He K,Hu Y,Ma H,Zou Z,Xiao Y,Yang Y,Feng M,Li X,Ye X

Thu Sep 01 00:00:00 EDT 2016

Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest.

Shock (Augusta, Ga.)

Xie X,Zhang J,Chen D,Pan H,Wu Z,Ge D,Yang G

Fri May 01 00:00:00 EDT 2015

Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest.

Shock (Augusta, Ga.)

Xie X,Zhang J,Chen D,Pan H,Wu Z,Ge D,Yang G

Fri May 01 00:00:00 EDT 2015

Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression.

Scientific reports

Yu SX,Du CT,Chen W,Lei QQ,Li N,Qi S,Zhang XJ,Hu GQ,Deng XM,Han WY,Yang YJ

Fri Dec 11 00:00:00 EST 2015

Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression.

Scientific reports

Yu SX,Du CT,Chen W,Lei QQ,Li N,Qi S,Zhang XJ,Hu GQ,Deng XM,Han WY,Yang YJ

Fri Dec 11 00:00:00 EST 2015

Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression.

Scientific reports

Yu SX,Du CT,Chen W,Lei QQ,Li N,Qi S,Zhang XJ,Hu GQ,Deng XM,Han WY,Yang YJ

Fri Dec 11 00:00:00 EST 2015

Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression.

Scientific reports

Yu SX,Du CT,Chen W,Lei QQ,Li N,Qi S,Zhang XJ,Hu GQ,Deng XM,Han WY,Yang YJ

Fri Dec 11 00:00:00 EST 2015

PI3K/Akt/uncoupling protein 2 signaling pathway may be involved in cell senescence and apoptosis induced by angiotensin II in human vascular endothelial cells.

Molecular biology reports

Li P,Guo X,Lei P,Shi S,Luo S,Cheng X

Wed Oct 01 00:00:00 EDT 2014

PI3K/Akt/uncoupling protein 2 signaling pathway may be involved in cell senescence and apoptosis induced by angiotensin II in human vascular endothelial cells.

Molecular biology reports

Li P,Guo X,Lei P,Shi S,Luo S,Cheng X

Wed Oct 01 00:00:00 EDT 2014

Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis.

PloS one

Hanaoka Y,Yasuda O,Soejima H,Miyata K,Yamamoto E,Izumiya Y,Maeda N,Ohishi M,Rakugi H,Oike Y,Kim-Mitsuyama S,Ogawa H

Fri Jan 16 00:00:00 EST 2015

Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis.

PloS one

Hanaoka Y,Yasuda O,Soejima H,Miyata K,Yamamoto E,Izumiya Y,Maeda N,Ohishi M,Rakugi H,Oike Y,Kim-Mitsuyama S,Ogawa H

Fri Jan 16 00:00:00 EST 2015

Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin.

Cell cycle (Georgetown, Tex.)

Sanchez-Alvarez R,Martinez-Outschoorn UE,Lamb R,Hulit J,Howell A,Gandara R,Sartini M,Rubin E,Lisanti MP,Sotgia F

Tue Jan 01 00:00:00 EST 2013

Uncoupling protein 2 expression affects androgen synthesis in polycystic ovary syndrome.

Endocrine

Liu Y,Jiang H,Xing FQ,Huang WJ,Mao LH,He LY

Sat Jun 01 00:00:00 EDT 2013

Uncoupling protein 2 expression affects androgen synthesis in polycystic ovary syndrome.

Endocrine

Liu Y,Jiang H,Xing FQ,Huang WJ,Mao LH,He LY

Sat Jun 01 00:00:00 EDT 2013

Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.

Reproduction, fertility, and development

Liu Y,Jiang H,He LY,Huang WJ,He XY,Xing FQ

Tue Sep 27 00:00:00 EDT 2011

Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.

Reproduction, fertility, and development

Liu Y,Jiang H,He LY,Huang WJ,He XY,Xing FQ

Tue Sep 27 00:00:00 EDT 2011

Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.

Reproduction, fertility, and development

Liu Y,Jiang H,He LY,Huang WJ,He XY,Xing FQ

Tue Sep 27 00:00:00 EDT 2011

Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.

Reproduction, fertility, and development

Liu Y,Jiang H,He LY,Huang WJ,He XY,Xing FQ

Tue Sep 27 00:00:00 EDT 2011

Bioinformatics

Protein Aliases: Dicarboxylate carrier SLC25A8; Dicarboxylate carrier UCP2; Mitochondrial uncoupling protein 2; Solute carrier family 25 member 8; UCP 2; UCPH; uncoupling protein; uncoupling protein 2 (mitochondrial, proton carrier); Uncoupling protein 2, mitochondrial

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Gene Aliases: BMIQ4; SLC25A8; UCP2; UCPH

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UniProt ID: (Human) P55851, (Rat) P56500, (Mouse) P70406

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Entrez Gene ID: (Human) 7351, (Rat) 54315, (Mouse) 22228

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Function(s)

structural constituent of ribosome protein binding molecular_function transporter secondary carrier transporter

Process(es)

response to superoxide response to hypoxia translation transport mitochondrial transport female pregnancy aging positive regulation of cell death proton transport cellular response to insulin stimulus cellular response to amino acid starvation negative regulation of apoptotic process regulation of mitochondrial membrane potential negative regulation of insulin secretion involved in cellular response to glucose stimulus response to fatty acid cellular response to glucose stimulus liver regeneration response to glucose cellular response to hormone stimulus

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UCP2 Polyclonal Antibody

UCP2 Antibody (11081-1-AP) in IHC (P)

Product Details

11081-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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