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Positive test controls include: Mouse heart, Rat heart. The target is usually found in the following locations: Mitochondrion inner membrane, Multi-pass membrane protein.
Immunogen sequence: MVGLKPSDVP PTMAVKFLGA GTAACFADLV TFPLDTAKVR LQIQGENQAV QTARLVQYRG VLGTILTMVR TEGPCSPYNG LVAGLQRQMS FASIRIGLYD SVKQVYTPKG
The uncoupling protein UCP1 (formerly designated UCP) is an integral membrane protein unique to brown adipose tissue mitochondria. UCP1 forms a dimer that acts as a proton channel, which can uncouple oxidative phosphorylation by dissipating the electrochemical potential across the inner mitochondrial membrane. This process induces heat production in brown adipose tissue and is involved in regulation of body temperature and glucose metabolism. UCP2 is a structurally related protein that also uncouples mitochondrial respiration. It is more widely expressed in human and mouse tissues, including white adipose tissue and muscle, than is UCP1. UCP2 is thought to play a role in body weight regulation. An additional UCP family member, UCP3, is highly muscle specific and is possibly involved in the uncoupling of oxidative phosphorylation in skeletal muscle.
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Protein Aliases: mitochondrial uncoupling protein 3; Putative mitochondrial transporter UCP3; Solute carrier family 25 member 9; UCP 3; uncoupling protein; Uncoupling protein 3; uncoupling protein 3 (mitochondrial, proton carrier); Uncoupling protein 3, mitochondrial; Uncoupling protein-3
Gene Aliases: AI645527; SLC25A9; UCP-3; UCP3
UniProt ID: (Human) P55916, (Mouse) P56501, (Rat) P56499
Entrez Gene ID: (Human) 7352, (Mouse) 22229, (Rat) 25708
Molecular Function:
transporter
secondary carrier transporter
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