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            Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

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            • Primary Antibodies ›
            • UGT1A1 Antibodies

            Invitrogen

            UGT1A1 Polyclonal Antibody

            View all (10) UGT1A1 antibodies
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            Cite UGT1A1 Polyclonal Antibody

            • Antibody Testing Data (1)
            Application
            UGT1A1 Antibody in Western Blot (WB)
            Group 53 Created with Sketch.

            FIGURE: 1 / 1

            UGT1A1 Antibody (PA5-42553) in WB

            Western blot analysis of human muscle cells using an anti-UGT1A1 polyclonal antibody (Product # PA5-42553).
            View Product

            UGT1A1 Antibody in Western Blot (WB)

            Product Details

            PA5-42553

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            0.2-1 µg/mL
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            Synthetic peptide directed towards the N-terminal of human UGT1A1 (aa 36-85).
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.5 mg/mL

            Purification

            Affinity Chromatography

            Storage buffer

            PBS with 2% sucrose

            Contains

            0.09% sodium azide

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2609187

            Product Specific Information

            Peptide sequence: DGSHWLSMLG AIQQLQQRGH EIVVLAPDAS LYIRDGAFYT LKTYPVPFQR

            Sequence homology: Horse: 86%; Human: 100%; Mouse: 79%; Rat: 82%

            Target Information

            This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

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            Cite this product

            Bioinformatics

            Protein Aliases: bilirubin UDP-glucuronosyltranserase; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; Bilirubin-specific UDPGT isozyme 1; EC 2.4.1.17; HUG BR1; hUG-BR1; HUGBR1; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A isoform 1; UDP-glucuronosyltransferase 1A1; UDPGT 1-1; UGT 1A; UGT-1A; UGT1 01; UGT1*1; UGT1-01; UGT1.1; UGT1A1

            View more View less

            Gene Aliases: BILIQTL1; GNT1; HUG-BR1; UDPGT; UDPGT 1-1; UGT1; UGT1A; UGT1A1

            View more View less

            UniProt ID: (Human) P22309

            View more View less

            Entrez Gene ID: (Human) 54658

            View more View less

            Function(s)

            retinoic acid binding enzyme inhibitor activity steroid binding glucuronosyltransferase activity enzyme binding protein homodimerization activity protein heterodimerization activity glycosyltransferase

            Process(es)

            liver development bilirubin conjugation acute-phase response response to nutrient digestion steroid metabolic process estrogen metabolic process flavonoid biosynthetic process drug metabolic process organ regeneration response to lipopolysaccharide heme catabolic process response to drug retinoic acid metabolic process response to starvation negative regulation of catalytic activity negative regulation of steroid metabolic process heterocycle metabolic process flavone metabolic process cellular glucuronidation flavonoid glucuronidation xenobiotic glucuronidation biphenyl catabolic process cellular response to ethanol cellular response to glucocorticoid stimulus
            It has to be done as per old AB suggested Products section.
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            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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