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Product Details
17982-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
UGT8 Fusion Protein Ag12393 (38-402 aa encoded by BC075069)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody specifically recognizes the endogenous UGT8.
Immunogen sequence: FKTLASALH ERGHHTVFLL SEGRDIAPSN HYSLQRYPGI FNSTTSDAFL QSKMRNIFSG RLTAIELFDI LDHYTKNCDL MVGNHALIQG LKKEKFDLLL VDPNDMCGFV IAHLLGVKYA VFSTGLWYPA EVGAPAPLAY VPEFNSLLTD RMNLLQRMKN TGVYLISRLG VSFLVLPKYE RIMQKYNLLP EKSMYDLVHG SSLWMLCTDV ALEFPRPTLP NVVYVGGILT KPASPLPEDL QRWVNGANEH GFVLVSFGAG VKYLSEDIAN KLAGALGRLP QKVIWRFSGP KPKNLGNNTK LIEWLPQNDL LGHSKIKAFL SHGGLNSIFE TMYHGVPVVG IPLFGDHYDT MTRVQAKGMG ILLEWK (38-402 aa encoded by BC075069)
Target Information
UGT8 (UDP-galactose-ceramide galactosyltransferase, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase) is a 541 amino acid, single pass membrane protein of the UDP-glycosyltransferase family. UGT8 is believed to be primarily involved with the metabolism of sphingolipids and galactosylceramide biosynthesis. UGT8 is one of six genes whose elevated expression has been correlated with a significantly increased the risk of lung metastases in breast cancer patients. As such, UGT8 may be a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. UGT8 is ubiquitously expressed with highest levels found in central and peripheral nervous systems and is up-regulated in breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; CGalT; UDP galactosyltransferase 8; UDP galactosyltransferase 8A; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase 8; UDP-galactose-ceramide galactosyltransferase 8A; UDP-glucuronosyltransferase 8; uridine diphosphate glycosyltransferase 8
Gene Aliases: AI850488; AW455908; CGT; mCerGT; UGT4; UGT8; Ugt8a
UniProt ID: (Human) Q16880, (Rat) Q09426, (Mouse) Q64676
Entrez Gene ID: (Human) 7368, (Rat) 50555, (Mouse) 22239
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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