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Proteintech

UNC13A/Munc13-1 Polyclonal Antibody

3 References

View all (8) UNC13A antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (4)

Application

UNC13A/Munc13-1 Antibody in Western Blot (WB)

FIGURE: 1 / 4

UNC13A/Munc13-1 Antibody (55053-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 55053-1-AP) UNC13A/Munc13-1 antibody at dilution of 1:2,000 incubated at room temperature for 1.5 hours.

UNC13A/Munc13-1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

55053-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M sodium bicarbonate/0.1M glycine, pH 7.3, with 50% glycerol, 0.1M glycine

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody is specific to UNC13A.

Target Information

UNC13A, also named as KIAA1032, belongs to the unc-13 family. It plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. UNC13A is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. UNC13A is also involved in secretory granule priming in insulin secretion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A.

Nature

Ma XR,Prudencio M,Koike Y,Vatsavayai SC,Kim G,Harbinski F,Briner A,Rodriguez CM,Guo C,Akiyama T,Schmidt HB,Cummings BB,Wyatt DW,Kurylo K,Miller G,Mekhoubad S,Sallee N,Mekonnen G,Ganser L,Rubien JD,Jansen-West K,Cook CN,Pickles S,Oskarsson B,Graff-Radford NR,Boeve BF,Knopman DS,Petersen RC,Dickson DW,Shorter J,Myong S,Green EM,Seeley WW,Petrucelli L,Gitler AD

Tue Mar 01 00:00:00 UTC 2022

Structural and Functional Analysis of the CAPS SNARE-Binding Domain Required for SNARE Complex Formation and Exocytosis.

Cell reports

Zhou H,Wei Z,Wang S,Yao D,Zhang R,Ma C

Tue Mar 19 00:00:00 UTC 2019

Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa.

eLife

Fan F,Matsunaga K,Wang H,Ishizaki R,Kobayashi E,Kiyonari H,Mukumoto Y,Okunishi K,Izumi T

Tue Jul 04 00:00:00 UTC 2017

Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa.

eLife

Fan F,Matsunaga K,Wang H,Ishizaki R,Kobayashi E,Kiyonari H,Mukumoto Y,Okunishi K,Izumi T

Tue Jul 04 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Munc13-1; Protein unc-13 homolog A; unc13a

Gene Aliases: 2410078G03Rik; KIAA1032; Munc13-1; UNC13A; Unc13h1

UniProt ID: (Human) Q9UPW8, (Mouse) Q4KUS2, (Rat) Q62768

Entrez Gene ID: (Human) 23025, (Mouse) 382018, (Rat) 64829

Function(s)

syntaxin-1 binding diacylglycerol binding metal ion binding protein N-terminus binding SNARE binding protein binding protein domain specific binding protein homodimerization activity protein heterodimerization activity

Process(es)

positive regulation of neurotransmitter secretion exocytosis chemical synaptic transmission neurotransmitter secretion neuromuscular junction development regulation of synaptic vesicle priming synaptic vesicle docking synaptic vesicle priming synaptic vesicle maturation synaptic transmission, glutamatergic intracellular signal transduction regulation of short-term neuronal synaptic plasticity beta-amyloid metabolic process long-term synaptic potentiation innervation positive regulation of dendrite extension regulation of synaptic transmission, glutamatergic

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