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            • Primary Antibodies ›
            • USP15 Antibodies

            Proteintech

            USP15 Polyclonal Antibody

            20 References
            View all (13) USP15 antibodies
            Datasheet
            Protocols
            Questions & Answers
            Catalog # 14354-1-AP
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            Price (USD)
            492.00
            150 µL
             
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            Cite USP15 Polyclonal Antibody

            • Antibody Testing Data (10)
            Application
            USP15 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Group 53 Created with Sketch.

            FIGURE: 1 / 10

            USP15 Antibody (14354-1-AP) in IHC (P)

            Immunohistochemical analysis of paraffin-embedded Human renal cell carcinoma tissue slide using (Product # 14354-1-AP) USP15 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
            View Product

            USP15 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            USP15 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            USP15 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            USP15 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            USP15 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            USP15 Antibody in Western Blot (WB)
            USP15 Antibody in Western Blot (WB)
            USP15 Antibody in Western Blot (WB)
            USP15 Antibody in Western Blot (WB)
            USP15 Antibody in Immunoprecipitation (IP)

            Product Details

            14354-1-AP

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:500-1:2,000
            View 12 publications 12 publications

            Immunohistochemistry (IHC)

            -
            View 2 publications 2 publications

            Immunohistochemistry (Paraffin) (IHC (P))

            1:50-1:500
            -

            Immunocytochemistry (ICC/IF)

            -
            View 4 publications 4 publications

            Immunoprecipitation (IP)

            0.5-4.0 µg
            View 2 publications 2 publications
            Product Specifications

            Species Reactivity

            Human, Mouse, Rat

            Published species

            Bovine, Mouse

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            USP15 Fusion Protein Ag5703 (1-235 aa encoded by BC020688)
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.44 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            PBS, pH 7.3, with 50% glycerol

            Contains

            0.02% sodium azide

            Storage conditions

            -20°C

            Shipping conditions

            Wet ice (domestic); Dry ice (international)

            Product Specific Information

            Immunogen sequence: MAEGGAADL DTQRSDIATL LKTSLRKGDT WYLVDSRWFK QWKKYVGFDS WDKYQMGDQN VYPGPIDNSG LLKDGDAQSL KEHLIDELDY ILLPTEGWNK LVSWYTLMEG QEPIARKVVE QGMFVKHCKV EVYLTELKLC ENGNMNNVVT RRFSKADTID TIEKEIRKIF SIPDEKETRL WNKYMSNTFE PLNKPDSTIQ DAGLYQGQVL VIEQKNEDGT WPRGPSTPKK PLEQSC (1-235 aa encoded by B C020688)

            Target Information

            Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            Bioinformatics

            Protein Aliases: Deubiquitinating enzyme 15; deubiquitinating enzyme Ubp109; granule cell antiserum positive 18; MGC131982; MGC149838; MGC74854; Ubiquitin carboxyl-terminal hydrolase 15; Ubiquitin carboxyl-terminal hydrolase of 109 kDa; ubiquitin specific protease 15; Ubiquitin thioesterase 15; ubiquitin thiolesterase 15; Ubiquitin-specific-processing protease 15; Unph-2; Unph4

            View more View less

            Gene Aliases: 4921514G19Rik; AI327321; E430033I05Rik; Gcap18; KIAA0529; Ubp109; UNPH-2; UNPH4; USP15

            View more View less

            UniProt ID: (Human) Q9Y4E8, (Mouse) Q8R5H1, (Rat) Q9R085

            View more View less

            Entrez Gene ID: (Human) 9958, (Mouse) 14479, (Rat) 171329

            View more View less

            Function(s)

            cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity transforming growth factor beta receptor binding protein binding identical protein binding SMAD binding ubiquitinated histone binding catalytic activity peptidase activity cysteine-type peptidase activity hydrolase activity thiol-dependent ubiquitinyl hydrolase activity cysteine protease

            Process(es)

            ubiquitin-dependent protein catabolic process transforming growth factor beta receptor signaling pathway protein deubiquitination BMP signaling pathway monoubiquitinated protein deubiquitination histone H2B conserved C-terminal lysine deubiquitination pathway-restricted SMAD protein phosphorylation proteolysis proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteasomal protein catabolic process
            It has to be done as per old AB suggested Products section.
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