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Urocortin (UCN), a 40 amino acids neuropeptide widely distributed in the central nervous system (CNS), belongs to a family of structurally related peptides including corticotrophin releasing factor (CRF), sauvagine and urotensin I. Urocortin is derived from a larger precursor protein (pro-urocortin, also named corticotensin). Urocortin has biological actions similar to CRF such as stress-related endocrine, autonomic and behavioral responses in mammalian species. It is a potent stimulator of adrenocorticotropic hormone (ACTH) secretion by corticotroph cells from the anterior pituitary in vitro and in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: prepro-urocortin; Urocortin; urocortin, preproprotein
Gene Aliases: UCN; UI; UROC
UniProt ID: (Human) P55089
Entrez Gene ID: (Human) 7349
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