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Invitrogen
VASN Monoclonal Antibody (10)
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Product Details
MA5-30992
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
10
Immunogen
Recombinant Human Vasorin Protein (Met1-Pro575)
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786654
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human Vasorin.
Target Information
The VASN gene encodes the protein vasorin, a type I transmembrane protein involved in cellular signaling, vascular development, and tissue repair. Vasorin is characterized by its expression in various tissues, including vascular endothelial cells and smooth muscle cells, where it functions to modulate cell proliferation and differentiation. It plays a significant role in the regulation of vascular remodeling and homeostasis by interacting with signaling molecules like transforming growth factor-beta (TGF-ß), thereby influencing processes such as angiogenesis and wound healing. Vasorin is implicated in inhibiting TGF-ß signaling pathways, which are crucial for maintaining vascular integrity and preventing excessive fibrosis during tissue repair. Dysregulation of VASN expression can contribute to pathological conditions, including cardiovascular diseases and cancer, where abnormal vascular remodeling and cell proliferation are evident. Research into vasorin continues to explore its functional mechanisms and potential therapeutic applications in diseases characterized by vascular dysregulation and tissue remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein slit-like 2; slit-like 2; Vasorin
Gene Aliases: SLITL2; UNQ314/PRO357/PRO1282; VASN
UniProt ID: (Human) Q6EMK4
Entrez Gene ID: (Human) 114990
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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