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Positive test controls include: A-431, Mouse kidney. The target is usually found in the following locations: Cell junction, Cell projection, Cytoplasm, cytoskeleton, filopodium membrane, focal adhesion, lamellipodium membrane, tight junction.
Immunogen sequence: AQFAAGMASA LEALEGGGPP PPPALPTWSV PNGPSPEEVE QQKRQQPGPS EHIERRVSNA GGPPAPPAGG PPPPPGPPPP PGPPPPPGLP PSGVPAAAHG A
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Enah/Vasp-like; Vasodilator-stimulated phosphoprotein; VASP
Gene Aliases: VASP
UniProt ID: (Human) P50552, (Mouse) P70460
Entrez Gene ID: (Human) 7408, (Rat) 361517, (Mouse) 22323
Molecular Function: scaffold/adaptor protein
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