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Abnova
VNN1 Monoclonal Antibody (2B10)
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Product Details
H00008876-M05
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2B10
Immunogen
VNN1 (NP_004657, 298 a.a. approximately 397 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: KLLLSQLDSH PSHSAVVNWT SYASSIEALS SGNKEFKGTV FFDEFTFVKL TGVAGNYTVC QKDLCCHLSY KMSENIPNEV YALGAFDGLH TVEGRYYLQI
Target Information
Hematopoietic precursor cells migrate to the thymus, where they differentiate into mature T lymphocytes. GPI-anchored vanin-1 protein regulates the late adhesion steps of thymus homing of bone marrow precursor cells. Vanin-1 is ubiquitously expressed as a pantetheinase enzyme and catalyzes the hydrolysis of pantetheine for vitamin B5 recycling. The hydrolytic activity of vanin-1 generates the potent antioxidant cysteamine as a metabolite. As a membrane bound pantetheinase, vanin-1 provides the main source of cysteamine under normal physiological conditions. In mice, vanin-1 is expressed specifically in male Sertoli cells of the developing testis, where it aids in cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Pantetheinase; Pantetheine hydrolase; Tiff66; Vanin-1; Vanin1; vannin 1; Vascular non-inflammatory molecule 1
Gene Aliases: HDLCQ8; Tiff66; VNN1
UniProt ID: (Human) O95497
Entrez Gene ID: (Human) 8876
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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