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VNN1 Antibody (MA5-51153) in WB
Western blot analysis of VNN1 in various lysates. Samples were incubated with VNN1 monoclonal antibody (Product # MA5-51153) using a dilution of 0.2 µg/mL followed by HRP-Linked Caprine Anti-Mouse IgG secondary antibody at a dilution of 0.2 µg/mL. Lane 1: Porcine Kidney lysate; Lane 2: PC3 cell lysate.
Product Details
MA5-51153
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
D1
Immunogen
Recombinant Human VNN1 protein, Leu36-Leu223 (Accession #O95497)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3093354
Target Information
Hematopoietic precursor cells migrate to the thymus, where they differentiate into mature T lymphocytes. GPI-anchored vanin-1 protein regulates the late adhesion steps of thymus homing of bone marrow precursor cells. Vanin-1 is ubiquitously expressed as a pantetheinase enzyme and catalyzes the hydrolysis of pantetheine for vitamin B5 recycling. The hydrolytic activity of vanin-1 generates the potent antioxidant cysteamine as a metabolite. As a membrane bound pantetheinase, vanin-1 provides the main source of cysteamine under normal physiological conditions. In mice, vanin-1 is expressed specifically in male Sertoli cells of the developing testis, where it aids in cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Pantetheinase; Pantetheine hydrolase; Tiff66; Vanin-1; Vanin1; vannin 1; Vascular non-inflammatory molecule 1
Gene Aliases: HDLCQ8; Tiff66; VNN1
UniProt ID: (Pig) Q9BDJ5, (Human) O95497
Entrez Gene ID: (Pig) 397246, (Human) 8876
pantothenate metabolic process
acute inflammatory response
chronic inflammatory response
biotin metabolic process
nitrogen compound metabolic process
movement of cell or subcellular component
inflammatory response
response to oxidative stress
central nervous system development
single organismal cell-cell adhesion
positive regulation of T cell differentiation in thymus
innate immune response
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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